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تعداد نتایج: 63 فیلتر نتایج به سال:
Dear Sir, We previously reported the therapeutic potential of pevonedistat (TAK-924/MLN4924), a novel inhibitor of protein neddylation, in patients with acute myeloid leukemia (AML). Pevonedistat is a small-molecule inhibitor of the neural cell developmentally downregulated 8 (NEDD8)-activating enzyme, which processes NEDD8 for binding to target substrates. The most characterized NEDD8 target i...
The International Prognostic Index (IPI; age, the disease stage according to the Ann Arbor system, serum lactate dehydrogenase (LDH), Eastern Cooperative Oncology Group (ECOG) performance status (PS) and the presence of extranodal involvement (ENI)) has been the traditionally utilized prognostic tool for diffuse large B-cell lymphoma (DLBCL) treated with cyclophosphamide, doxorubicin, vincristi...
Here, we describe the cloning and characterization of ScII, the second most abundant protein after topoisomerase II, of the chromosome scaffold fraction to be identified. ScII is structurally related to a protein, Smclp, previously found to be required for accurate chromosome segregation in Saccharomyces cerevisiae. SclI and the other members of the emerging family of SMCl-like proteins are lik...
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