Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrates followed by decarboxylation, esterification and reductive cyclisation processes.

Various methacryloyloxymethylalkoxysilanes have been synthesized by nucleophilic substitution reactions starting from chloromethylalkoxysilanes under phase transfer catalysis conditions. The compounds thus obtained show an exceptionally high degree of reactivity with regard to hydrolysis and condensation both under acidic as well as under basic conditions compared to the established 3-methacryl...

Treatment of meso 2-ethylhexyl-3-mercaptopropionate substituted porphyrins with base at room temperature generated a porphyrin thiolate anion which in situ reacted in a nucleophilic aromatic substitution (SNAr) reaction with remaining thioether derivative. This reaction yielded S-linked bisporphyrins in good yields, with mechanistic insight obtained via displacement reactions. Additionally, SNA...

Nuclear magnetic resonance techniques were used to study the kinetics and products of the reaction of a variety of epoxides with various amines under varying pH conditions. In agreement with a previous finding, the amine-epoxide reactions were found to be water-catalyzed and not directly dependent on the pH of the reaction environment. At pH values higher than the pK(a) of the particular amine,...

As a novel Sanger-type reagent, 2-fluoro-5-nitrophenyldiazonium tetrafluoroborate enabled the versatile functionalization of primary and secondary aliphatic alcohols. Based on mild nucleophilic aromatic substitution fluorine atom under unprecedented, base-free conditions, diazonium unit core resulting aryl-alkyl ether could be employed for such diverse transformations as radical C-H activation ...