DNA breaks activate the DNA damage response and, if left unrepaired, trigger cellular senescence. Telomeres are specialized nucleoprotein structures that protect chromosome ends from persistent DNA damage response activation. Whether protection can be enhanced to counteract the age-dependent decline in telomere integrity is a challenging question. Telomeric repeat-containing RNA (TERRA), which ...

background: 3dcrt (three-dimensional conformal radiotherapy) and imrt (intensity-modulated radiotherapy) has provided us with tools to delineate the radiation dose distribution of tumor targets. however, the precision of radiation can be compromised by respiratory motion, which usually limits the geometric and dosimetric accuracy of radiotherapy. the purpose of this study is to evaluate the imp...

Mitochondrial diseases and aging are associated with defects in the oxidative phosphorylation machinery (OXPHOS), which are the only complexes composed of proteins encoded by separate genomes. To better understand genome coordination and OXPHOS recovery during mitochondrial dysfunction, we examined ATFS-1, a transcription factor that regulates mitochondria-to-nuclear communication during the mi...

Background: 3DCRT (three-dimensional conformal radiotherapy) and IMRT (intensity-modulated radiotherapy) has provided us with tools to delineate the radiation dose distribution of tumor targets. However, the precision of radiation can be compromised by respiratory motion, which usually limits the geometric and dosimetric accuracy of radiotherapy. The purpose of this study is to evaluate the imp...

Septic cardiac dysfunction is the main cause of death in septic patients. Here we investigate whether exogenous carbon monoxide can protect cardiac function and improve survival against sepsis by interfering with mitochondrial energetic metabolism. Male C57BL/6 mice were subjected to cecal ligation and puncture to induce sepsis. Exogenous carbon monoxide delivered from Tricarbonyldichlororuthen...

Acute respiratory distress syndrome (ARDS) is a disease of multifactorial etiology characterised by rapid development of severe diffuse and nonhomogenous inflammation of the pulmonary lobules causing life-threatening hypoxaemic respiratory failure. The current authors tested a therapeutic intervention on a previously defined pathophysiological model of ARDS. The model was defined by investigati...