Sotos syndrome is a genetic disorder characterized by overgrowth, megalocephaly, and mental retardation due to mutations or deletions in the nuclear receptor binding SET Domain protein 1 (NSD1) gene. We report case of with various oral symptoms.

Mammalian cell culture studies have shown that several members of the nuclear receptor super family such as glucocorticoid receptor, retinoic acid receptor and thyroid hormone receptor can repress the activity of AP-1 proteins by a mechanism that does not require the nuclear receptor to bind to DNA directly, but that is otherwise poorly understood. Several aspects of nuclear receptor function a...

The ability of NR LBDs to transfer repression function to a heterologous DNA binding domain, and the cross-squelching of repression by untethered LBDs, has suggested that repression is mediated by interactions with putative cellular corepressor proteins. The yeast-two hybrid screen for protein interactors has proven to be the key to the isolation and characterization of corepressors. This short...

This work was presented in part at the 53rd Annual Meeting of The American Thyroid Association, Cleveland, Ohio, 7-10 September 1977. Dr. Larsen is an Investigator of the Howard Hughes Medical Institute. Received for publication 29 August 1977 and in revised form 11 January 1978. well with both the change in TSH and the nuclear occupancy, suggesting a linear relationship between the integrated ...

Nuclear receptors are one of the most abundant classes of transcriptional regulators in animals (metazoans). They regulate diverse functions, such as homeostasis, reproduction, development and metabolism (for a review, see Laudet and Gronemeyer, 2002). Nuclear hormone receptors function as ligandactivated transcription factors, and thus provide a direct link between signaling molecules that con...

Objective(s): To validate the reliability of nuclear medicine physicians in diagnosing lymphoma using positron emission tomography/computed tomography using 2-deoxy-2-[18F]fluoro-D-glucose (FDG-PET/CT) and to determine findings that reliably suggest lymphoma.Methods: Seventy patients suspected of having lymphoma using FDG-PET/CT were enrolled in this retrospective study. Two nuclear medicine ph...

Brain-derived neurotrophic factor (BDNF) is known to be crucial for the development of peripheral vestibular neurons. However, the maturation profile of the BDNF signal transducing receptor, tyrosine kinase B (TrkB) in functionally activated otolith-related vestibular nuclear neurons of postnatal rats remains unexplored. In the present study, conscious Sprague-Dawley rats (P4 to adult) were sub...

Retinoic acid receptor-related orphan receptors (ROR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [11, 3]) have yet to be assigned a definitive endogenous ligand, although RORα may synthesized with ‘captured’ agonist such cholesterol [68, 67].