نتایج جستجو برای: nuclear localization

تعداد نتایج: 363249  

Journal: :Nucleic Acids Symposium Series 1999

Journal: :Molecular and Cellular Biology 2001

Journal: :Journal of Biological Chemistry 2001

Journal: :Cancer research 2005
Ji-Hyun Chung Margaret E Ginn-Pease Charis Eng

Although phosphatase and tensin homologue deleted on chromosome 10 (PTEN) localization in the nucleus and cytoplasm is established, the mechanism is unknown. PTEN is a tumor suppressor phosphatase that causes cell cycle arrest and/or apoptosis. Nuclear-cytoplasmic compartmentalization may be a novel mechanism in regulating these events. PTEN does not contain a traditional nuclear localization s...

Journal: :Bioinformatics 2011
Ahmed M. Mehdi Muhammad Shoaib B. Sehgal Bostjan Kobe Timothy L. Bailey Mikael Bodén

MOTIVATION Nucleo-cytoplasmic trafficking of proteins is a core regulatory process that sustains the integrity of the nuclear space of eukaryotic cells via an interplay between numerous factors. Despite progress on experimentally characterizing a number of nuclear localization signals, their presence alone remains an unreliable indicator of actual translocation. RESULTS This article introduce...

2013
Laura R. Johnson James D. Robinson Katrina N. Lester Julie A. Pitcher

G protein-coupled receptor kinases (GRKs) act to desensitize G protein-coupled receptors (GPCRs). In addition to this role at the plasma membrane, a nuclear function for GRK5, a member of the GRK4 subfamily of GRKs, has been reported. GRK5 phosphorylates and promotes the nuclear export of the histone deacetylase, HDAC5. Here we demonstrate that the possession of a nuclear localization sequence ...

2017
Niina A Koistinen Anna K Edlund Preeti K Menon Elena V Ivanova Smaranda Bacanu Kerstin Iverfeldt

Fe65 is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-β precursor protein, APP. Here, the subcellular localization was further investigated using TAP-tagged Fe65 constructs expressed in human neuroblastoma cells. Our results indicate that PTB2 rather than the WW domain is important for the nuclear localization of Fe65. Electrophoretic mobility ...

Journal: :Annual review of microbiology 1998
V W Pollard M H Malim

The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal. These essential peptide motifs have now been shown to function by accessing cellular signal-mediated pathways for n...

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