Department of Nuclear Medicine, Seoul National University Boramae Medical Center, Seoul; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul; Department of Family Medicine, Incheon St. Mary’s Hospital, The Catholic University of Korea School of Medicine, Incheon; Department of Family Medicine & Geriatrics, National Health Insurance Corporation Ilsan Hospital, Go...

Yeast cells mutated in YRB2, which encodes a nuclear protein with similarity to other Ran-binding proteins, fail to export nuclear export signal (NES)-containing proteins including HIV Rev out of the nucleus. Unlike Xpo1p/Crm1p/exportin, an NES receptor, Yrb2p does not shuttle between the nucleus and the cytoplasm but instead remains inside the nucleus. However, by both biochemical and genetic ...

The human malaria parasite Plasmodium falciparum modifies the erythrocyte it infects by exporting variant proteins to the host cell surface. The var gene family that codes for a large, variant adhesive surface protein called P. falciparum erythrocyte membrane protein 1 (PfEMP1) plays a particular role in this process, which is linked to pathogenesis and immune evasion. A single member of this g...

BACKGROUND In recent years, psychologists of health have attempted to understand the relations between family dynamics and health. The aim of our study is not only to study relations inside families and couples (relations between family of origin, nuclear and ideal family, current and ideal couple) but also outside between families and couples and different health indicator (physical and mental...

The importance of the Bcl-2 family proteins in normal vertebrate embryogenesis is being recognized; however, their regulatory mechanism is poorly understood. To elucidate the embryonic roles of Bcl-2 family proteins, we cloned and characterized the first zebrafish Bcl-2 family protein, zfMcl-1a. Zebrafish Mcl-1a shows the highest homology to rat Mcl-1 and contains several conserved BH domains o...

Research showed that following the birth of a first child, parents increase contact with family members and diminish contact with friends, however, these changes may differ when conception is achieved through assisted reproductive technologies (ART). Based on the convoy model (Kahn & Antonucci, 1980) perspective of close relationships, we examined changes across the transition to parenthood in ...

Pre-mRNAs are associated with hnRNPs, and these proteins play important roles in the biogenesis of mRNAs. The hnRNP A1 is one of the most abundant hnRNPs, and although localized primarily in the nucleoplasm, shuttles continuously between the nucleus and the cytoplasm. A 38 amino acid domain within A1, termed M9, which bears no resemblance to classical nuclear localization signal (NLS) sequences...

DNA methylation plays important roles in gene regulation and functions. Aberrant methylation, either hypomethylation or hypermethylation, has been reported to cause various diseases, especially cancers. Breast cancer ranked the fifth according to the number of cancer deaths in the world. To systematically characterize the epigenetic modification in breast cancer, we examined the genome-wide met...

The virus of parrots and parrakeets discovered by Pacheco, Bier, and Meyer is unrelated to the agent causing psittacosis either in birds or in man. The virus is fairly species-specific and manifests itself chiefly by the production of areas of focal necrosis in the liver and acidophilic intranuclear inclusions in affected cells.