Using the whole-cell voltage-clamp method, we investigated the effect of fluvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, on lysophosphatidylcholine (LPC)-induced nonselective cation current (I(NSC)) in guinea pig cardiac ventricular myocytes. External LPC (3 to approximately 50 microM) induced I(NSC) in a dose-dependent manner with a lag. With fluvastatin (5 microM) in the ex...

In this section we provide a detailed derivation of the expected noise correlations across scales, E[< nsc, n >], referred to in Section 3 of the paper. For simplicity, let us first derive the expression for the 1D case. Let us denote a 1D noise patch, containingM = 2m+1 pixels and centered around a specific coordinate l in the noisy image N by: n = (Nl−m, ..., Nl+m). Let us denote by lsc the s...

Untreated caries is significant problem that affected billion people over the world. Therefore, appropriate method and accuracy of detection in clinical decision-making dental practices as well oral epidemiology or research, are required urgently. The aim this study was to introduce a computational algorithm can automate recognize carious lesions on tooth occlusal surfaces smartphone images acc...

2, 5-bis(5-Hydroxymethyl-2-thienyl)furan (NSC 652287), is a representative of a series of thiophene derivatives that exhibit potent and selective antitumor activity against several tumor cell lines in the National Cancer Institute Anticancer Drug Screen. NSC 652287 has noticeable activity for the renal cell lines and produces cures in certain corresponding xenografts. The cellular mechanisms of...

BACKGROUND Non-specific complaints (NSC) are common at the emergency department, but only a few studies have shown evidence that these complaints are associated with a poor prognosis in elderly emergency patients. OBJECTIVE To describe patient characteristics and outcomes in a cohort of elderly emergency patients presenting with NSC. Outcomes were: patient characteristics, hospitalization, 90...

The effect of hydroxylamine (NSC-26250) and related compounds has been examined on the growth of 11 transplanted mouse tumors, including 3 leukemias, and 1 rat tumor. By the end of therapy hydroxyurea (NSC-32065) and its 1-methyl (NSC-529064) and 1-ethyl (NSC-50840) derivatives retarded the growth of 9 tumors, and hydroxyurethan (NSC-71045; hydroxycarbamic acid ethyl ester) and N, 0-diacetyl-^-...

BACKGROUND We are developing cell-based assays to identify anticancer agents that are selectively toxic to cells with defined mutations. As a test, we used a three-stage strategy to screen compounds from the National Cancer Institute's repository for agents that are selectively toxic to double-strand break repair-deficient yeast cells. METHODS Compounds identified in the screen were further a...

A digestion study with 28 yearling heifers (428 +/- 9.9 kg; Exp. 1) and a 2-yr winter grazing trial with 60 crossbred cows (552 +/- 6.9 kg; Exp. 2) were used to determine the effects of level of nonstructural carbohydrate (NSC) supplementation on intake and digestibility of low-quality forage. Treatments were as follows: 1) control, no supplement; 2) 0.32 kg of NSC (1.8 kg/d of soybean hulls an...

The ability to identify human neural stem cells (NSC) by brain imaging may have profound implications for diagnostic, prognostic, and therapeutic purposes. The study of human NSC in vivo is hindered by the absence of well-defined markers that can distinguish them from other neural cell types. We have, however, identified a NSC-specific metabolic peak using H-NMR spectroscopy of cultured, purifi...

Nearest shrunken centroid classifier (NSC) is a class of linear classifiers with built-in feature selections, and has proven useful for analyzing microarray data. The simple linear structure of the classification boundary makes NSC easy to interpret and implement, but sometimes this simple structure might fail to generalize well for some data. In this paper we propose boosting NSC to improve it...