Cyclooxygenases (Cox) are rate-limiting enzymes that initiate the conversion of arachidonic acid to prostanoids. Cox-2 is the inducible isoform that is upregulated by proinflammatory agents, initiating many prostanoid-mediated pathological aspects of inflammation. In this study, we demonstrate that interferon (IFN)-gamma alone or in synergy with lipopolysaccharide (LPS) or interleukin 1alpha in...

Cyclooxygenases (Cox) are rate-limiting enzymes that initiate the conversion of arachidonic acid to prostanoids. Cox-2 is the inducible isoform that is upregulated by proinflammatory agents, initiating many prostanoid-mediated pathological aspects of inflammation. In this study, we demonstrate that interferon (IFN)g alone or in synergy with lipopolysaccharide (LPS) or interleukin 1 a induces Co...

background: nepeta dschuparensis bornm (np) is used as a medicinal herb in iran. in traditional medicine, this herb is extensively employed for curing ailments such as cardiovascular diseases. np has antioxidant and anti-inflammatory properties. this project examined the effects of the np extract on cyclooxygenase-2 (cox-2) and interleukin-1β (il-1β) protein levels and its efficacy in neuroprot...

BACKGROUND Mild cognitive impairment (MCI) is considered a clinical stage between normal cognitive aging and dementia. The clinical course of MCI is heterogeneous, with a significant number of cases progressing to dementia or reverting back to normal. OBJECTIVE To determine the predictors of conversion from mild cognitive impairment to dementia among Mexican older adults. MATERIALS AND METH...

Prostaglandin endoperoxide H synthase (PGHS) catalyzes the conversion of arachidonic acid to PGH2, the first committed step in the biosynthesis of a range of lipid mediators, termed prostaglandins (PGs) and thromboxanes.1 PGHS has both cyclooxygenase (COX) and hydroperoxidase activities.2 Aspirin and a variety of nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the COX activity of PGHS3 (Fi...

Cyclooxygenases (COX) are rate-limiting enzymes involved in the conversion of PLA(2)-mobilized arachidonic acid into prostaglandins and thromboxanes. COX-2 is a key mediator of inflammation during both physiologic and pathologic responses to endogenous stimuli and infectious agents. Its overexpression has been detected in different cancers, including that of the breast. Using RNA interference, ...