Using a perfused innervated rat heart model, we studied the sex difference in the sympathetic nerve stimulation-induced norepinephrine release and its presynaptic alpha 2-adrenergic inhibition in normoxic and ischemic conditions. During normoxic perfusion, the alpha 2-adrenoceptor antagonist rauwolscine resulted in a higher overflow of norepinephrine during nerve stimulation in females than in ...

Kawanabe, Yoshifumi, Nobuo Hashimoto, and Tomoh Masaki. Characterization of G proteins involved in activation of nonselective cation channels and arachidonic acid release by norepinephrine/ 1Aadrenergic receptors. Am J Physiol Cell Physiol 286: C596–C600, 2004; 10.1152/ajpcell.00359.2003.—We demonstrated recently that norepinephrine activates Ca -permeable nonselective cation channels (NSCCs) i...

BACKGROUND Vascular hyporeactivity to catecholamines limits successful treatment of hypotension in septic shock. Large amounts of nitric oxide (NO) and superoxide anion (O(2)(-1).) are produced in response to bacterial endotoxins and/or inflammatory cytokines. NO reacts with O(2)(-1). to form the potentially toxic NO metabolite, peroxynitrite (ONOO(-1)). The purpose of this study was to investi...

Sympathoexcitation, increased circulating norepinephrine, and elevated levels of reactive oxygen species are driving forces underlying numerous cardiovascular diseases, including hypertension. However, the effects of elevated norepinephrine and subsequent reactive oxygen species production in splenic T-lymphocytes during hypertension are not currently understood. We hypothesized that increased ...

The objective of this research was to develop robust predictive models the gains in working memory (WM) and fluid intelligence (Gf) following executive attention training children, using genetic markers, gender, age variables. We explore influence variables on individual differences susceptibility intervention. Sixty-six children (males: 54.2%) aged 50.9–75.9 months participated a four-weeks co...

conclusions the results of the study show no significant association between norepinephrine transporter polymorphism scl6a2 and adhd. results the percentages of adhd subtypes for combined, inattentive, and hyperactive/impulsive were 72.2%, 17.2%, and 11.9%, respectively. there was no significant association between norepinephrine transporter polymorphism and adhd (p = 0.81). moreover, no signif...

or provide information about other aspects of sympathetic function. This report examines how cardiac spillover of the norepinephrine metabolite dihydroxyphenylglycol (DHPG) provides additional distinct information about cardiac sympathetic function. Methods and Results. Arterial and coronary venous blood samples were taken during cardiac catheterization and intravenous infusion of [3Hlnorepinep...

The sympathetic nervous system, via norepinephrine, regulates renal sodium transport, and chronic sympathetic activation causes sustained increases in blood pressure by reducing sodium excretion. Our previous studies show that chronic norepinephrine infusion increases the abundance of the bumetanide-sensitive cotransporter type 1, the apical sodium transporter of the thick ascending limb of Hen...

Angiogenesis is an important factor in invasive tumor growth, progression, and metastasis. Multiple proangiogenic mechanisms are involved in tumor angiogenesis. In this study, we showed that the neurotransmitter norepinephrine upregulated VEGF (VEGFA) expression in breast cancer cells and that the culture supernatant from norepinephrine-treated breast cancer cells promoted the formation of the ...