Lipopolysaccharide-enhanced secretion of non-immunoglobulin proteins by bone marrow cells derived from responder, nonresponder, and low-responder mouse strains did not precisely correlate with the lipopolysaccharide responsiveness assessment based on the mitogenic reactivity of splenocytes. These findings suggest that enhancement of secretion of non-immunoglobulin protein may be useful for furt...

A cell wall protein that is ordinarily complexed to the lipopolysaccharide endotoxin in gram-negative bacteria has been separated by the use of aqueous phenol. The protein is active as a B-cell mitogen and polyclonal activator of murine lymphocytes including the C3H/HeJ strain which is a nonresponder to lipoplysaccharide or lipid A.

We report a patient who did not improve after standard optimization of atrioventricular and intraventricular pacing timing, but showed response to cardiac resynchronization therapy (CRT) after increasing left ventricular (LV) pacing output. Increasing LV pacing output is one of the useful optimization methods for CRT nonresponder.

The development of nonsurgical contraceptives for cats may facilitate population control of the species. The purpose of this study was to investigate the utility of GnRH for immunocontraception of male cats. Male cats (n=12) were divided into groups of three and were immunized once with 0 (sham), 50, 200, or 400 microg synthetic GnRH coupled to keyhole limpet hemocyanin and combined with a myco...

BACKGROUND Pegylated interferon plus ribavirin therapy for hepatitis C virus (HCV) fails in approximately half of genotype 1 patients. Treatment failure occurs either by nonresponse (minimal declines in viral titer) or relapse (robust initial responses followed by rebounds of viral titers during or after therapy). HCV is highly variable genetically. To determine if viral genetic differences con...

Immune responses to the synthetic polypeptide poly(LTyr,LGlu)-poly(DLAla)-poly(LLys) [(T,G)-A--L] 1 (1), such as humoral responses (2), delayed-type hypersensitivity responses (DTH) (3), and antigen-dependent T-cell proliferation, (4) are regulated by genes that are located in the major histocompatibility complex of the mouse (H-2). Thus, mice possessing the H-2 b haplotype are responders and m...

OBJECTIVE The aim of this study was to investigate whether the level of serum microRNA-199a/b-3p (miR-199a/b-3p) can serve as a predictor of treatment response to transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). METHODS Serum miR-199a/b-3p expression level was measured in 132 patients with HCC before TACE (t1) and 3-5 days after TACE (t2). Additionally, ...

Immunization of mice bearing the nonresponder haplotypes, H 2 ~" q" s. with the terpolymer L-glutamic acid6°-L-alanine3°-L-tyrosine TM (GAT) 1 stimulates suppressor T cells (Ts) that specifically inhibit GAT-specific IgG plaque-forming cell (PFC) responses by syngeneic mice to GAT complexed to the immunogenic carrier methylated bovine serum albumin (GAT-MBSA) in vitro and in vivo (1, 2). Analog...