Amphotericin B (AB) at micromolar concentrations increases cell membrane permeability and induced swelling of rat thymus lymphocytes. Potassium efflux is a precondition for AB to induce swelling of the cells. The rate constants for potassium loss and volume changes were proportional to the 1.24th and the 2nd power of the antibiotic concentration respectively. The reflection coefficients for non...

Two new heterocyclic Schiff bases of 4-amino-5-mercapto-3-H/propyl-1,2,4-triazole and 5-nitrofurfuraldehyde [HL(1-2)] and their cobalt, nickel, copper, and zinc complexes have been synthesized and characterized by elemental analyses, spectral (UV-Vis, IR, (1)H NMR, Fluorescence, and ESR) studies, thermal techniques, and magnetic moment measurements. The heterocyclic Schiff bases act as bidentat...

In the endeavor to identify a mathematical model predictive of the mostly unexplored skin penetration of fragrance chemicals, the Potts-Guy equation was tested here by correlating the published, measured Kp for 20 such compounds with predicted Kp values. The data, covering a broad range of structures, are well described by that model (r 2 = 0.86, p < 0.001). Also, calculated octanol-water parti...

Single isolated muscle fibers from the walking legs of the blue crab, Callinectes sapidus act as Boyle-van't Hoff osmometers with an osmotically inactive volume of 33 %. Fibers in hypotonic salines undergo a spontaneous volume readjustment toward the initial volumes of the cells found in isotonic salines. The volume readjustment is initiated by the increase in cell volume in hypotonic salines a...

Schiff base has been prepared by the condensation of 2-naphthylamine (NA) with 5bromosalicylaldehyde (BSA). The ligand (NABSA) was isolated and characterized. Metal complexes have been synthesized by the interaction of NABSA with metal ions viz. Co(II), Ni (II), and Cu(II) in 1:2 molar ratio respectively. These complexes have been characterized by FT-IR, electronic spectroscopy, conductance mea...

Enthalpies of solution of electrolytes as well as nonelectrolytes in several pure and mixed solvents are discussed. The resulting enthalpies of transfer from one solvent to another in solvent systems containing water show the influence of hydrophobic hydration for solutes containing alkyl groups, viz. tetraalkylammonium bromides, alkanols and substituted ureas. Enthalpies of dilution give infor...

The reflection coefficient was originally introduced by Staverman to describe the movement of nonelectrolytes through membranes. When this coefficient is extended to salts, one has a choice of defining this term for the whole salt moving as a single electrically neutral component or for the individual ions of the salt. The latter definition is meaningful only in the absence of an electric field...