1. Where we are: Segre classes of vector bundles, and Segre classes of cones 1 1.1. Segre classes of cones 1 2. What the “functoriality of Segre classes of subschemes” buys us 2 2.1. The multiplicity of a variety along a subvariety 2 3. Deformation to the normal cone 3 3.1. The construction 3 4. Specialization to the normal cone 5 4.1. Gysin pullback for local complete intersections 6 4.2. Inte...

The cone electroretinogram has been examined at different levels of ganzfeld adaptation in normals and subjects with retinitis pigmentosa (RP). As light adaptation increases, the amplitude and time course (measured as b-wave implicit time) of the cone ERG decrease in both normal and RP subjects. The same level of light adaptation, however, decreases the amplitude and the implicit time more in n...

PURPOSE To develop methods for recording human electroretinogram (ERG) responses to stimuli that modulate different classes of cones in various ratios, to draw inferences about the combination of cone signal in early retinal processing. METHODS Subjects viewed large-field temporal modulations presented on a computer-controlled color monitor. A flicker photometric paradigm was used to equate t...

In this paper, optimality conditions for the group sparse constrained optimization (GSCO) problems are studied. Firstly, equivalent characterizations of Bouligand tangent cone, Clarke cone and their corresponding normal cones set derived. Secondly, by using cones, four types stationary points GSCO given: TB-stationary point, NB-stationary TC-stationary point NC-stationary which used to characte...

The big eye kilka, Clupeonella grimmi, is a marine fish living in depth of 20 to 200 meter of the Caspian Sea. Its eye and retina were processed for histological and SEM studies. Paraffin embedded retina was cut radially and tangentially in 5 ?m thickness and stained with hematoxylin and eosin method. The unstained sections were manipulated for SEM image observations. Tangential retinal sect...

Mammalian cones respond to light by closing a cGMP-gated channel via a cascade that includes a heterotrimeric G-protein, cone transducin, comprising Gαt2, Gβ3 and Gγt2 subunits. The function of Gβγ in this cascade has not been examined. Here, we investigate the role of Gβ3 by assessing cone structure and function in Gβ3-null mouse (Gnb3(-/-)). We found that Gβ3 is required for the normal expres...

Using variational analysis, we study vector optimization problems with objectives being closed multifunctions on Banach spaces or in Asplund spaces. In particular, in terms of the coderivatives, we present Fermat’s rules as necessary conditions for an optimal solution of the above problems. As applications, we also provide some necessary conditions (in terms of Clarke’s normal cones or the limi...

OBJECTIVES To describe the clinical, perimetric, and electroretinographic (ERG) results of 4 patients with cone dysfunction following irofulven treatment including the histopathologic and immunocytochemical features of one patient's retinas. DESIGN Observational case series. METHODS The patients were examined clinically, including perimetric and ERG evaluations. Eyes from patient 1 and heal...