utaneous foot melanoma is rare; it accounts for approximately 1% of all cutaneous melanoma and can be challenging to manage [1]. There are four main variants of cutaneous malignant melanomas (CMMs), superficial spreading melanoma (SSM), lentigo malignant melanoma (LMM), nodular melanoma (NM) and acral lentiginous melanoma (ALM). Superficial spreading melanoma accounts for approximately 65% of a...

We describe a patient with disseminated metastases from malignant melanoma manifested as symptomatic tachycardia and bradycardia that mimicked sick sinus syndrome. Autopsy showed extensive invasion of the right atrium by nodular disease.

BACKGROUND Cutaneous melanoma is a highly aggressive malignancy with increasing incidence worldwide. The southern Brazilian state of Santa Catarina has one of the highest incidence rates of melanoma in the country. OBJECTIVE To evaluate the epidemiological profile of melanoma patients in a southern city of Brazil. METHODS a cross-sectional retrospective study was conducted, aiming to detect...

  Absract   Intracranial invasion of cellular blue nevus (CBN) from the skin is extremely rare   and such a condition with malignant transformation is even rarer. A case of   meningeal melanoma with malignant transformation which was derived from an Ota   nevus is presented in this report.   A21-year-old man with a neurocutaneous syndrome since childhood was referred   with headache and mild le...

Melanoma is a lethal skin cancer that occurs predominantly among Caucasians. In Malaysia, the incidence of melanoma is low. This is a retrospective study of clinical and histopathological features of patients with cutaneous melanoma who were seen at the University Malaya Medical Centre from 1998 to 2008. Thirty-two patients with cutaneous melanoma were recorded during that period. Of these, 24 ...

The Malignant melanoma is an uncommon primary malignant tumour of the foot.1 It occurs in different forms like superficial spreading, nodular, lentiginous and acral. Amelanotic/ hypomelanotic melanoma is a non-pigmented variety of cutaneous melanoma accounting for 2-8% of all primary melanomas.2,3 The lesion is usually exophytic and ulcerative with or without metastasis. The lesions usually beg...

INTRODUCTION Primary malignant melanoma is an uncommon skin tumour in Singapore compared with the Western countries. The clinical characteristics of melanoma have been rarely reported in Asians. OBJECTIVES Our purpose was to study the incidence, clinical characteristics and risk factors of biopsy proven malignant melanoma seen in a tertiary referral skin hospital. METHODS Case records of pa...

We examined liver specimens from 15 patients with uveal melanoma (UM) who had died of their disseminated disease. We found 2 distinct growth patterns of UM metastasis: infiltrative (n = 12) and nodular (n = 3). In the infiltrative pattern, individual UM cells with a CD133+ cancer stem cell-like phenotype were present and formed aggregates of stage I <50-μm-diameter micrometastases in the sinuso...

We examined 172 primary (110 superficial and 62 nodular) and 73 metastatic melanomas, as well as 10 benign nevi, for protein expression of cyclin D1 and cyclin D3 and evaluated the relationship between deregulated protein levels and clinical outcome. For both proteins, a heterogeneous nuclear staining pattern was observed. Cyclin D3 was expressed by 96% of primary and 97% of metastatic melanoma...