The conclusion of Kooga et al. [1] that ‘‘the nocebo effect of acupuncture is clinically meaningful and the rate of patients with any adverse event may be a more appropriate indicator of the nocebo effect’’ deserves some comments. First, opposing placebo and nocebo is a misconception. Indeed, conditioning and expectations are the main factors triggering a response, whether positive or negative....

INTRODUCTION Placebo and nocebo represent complex and distinct psychoneurobiological phenomena in which behavioural and neurophysiological modifications occur together with the application of a treatment. Despite a better understanding of this topic in the medical field, little is known about their role in physiotherapy. PURPOSE The aim of this review is: a) to elucidate the neurobiology behi...

Background: Placebo and nocebo responses have important consequences for the development of pharmaceutical drugs design randomized controlled trials (RCTs). They can lead to incorrect measurement treatment-related efficacy adverse effects (AEs). Objectives: The goal this study was evaluate frequency magnitude placebo in placebo-controlled RCTs non-tumor necrosis factor (TNF) biologics Janus kin...

In modern medicine, the placebo response or placebo effect has often been regarded as a nuisance in basic research and particularly in clinical research. The latest scientific evidence has demonstrated, however, that the placebo effect and the nocebo effect, the negative effects of placebo, stem from highly active processes in the brain that are mediated by psychological mechanisms such as expe...

Pharmacogenetic testing holds great promise to improve health outcomes and reduce adverse drug responses through enhanced selection of therapeutic agents. Since drug responses can be manipulated by verbal suggestions, it is of particular interest to understand the potential impact of pharmacogenetic test results on drug response. Placebo and nocebo-like effects may be possible due to the sugges...

Background Social observation is one of the main ways to gain experience. Similar to first-person experience, observational experience affects the effectiveness of subsequent treatments. Yet, it is still undetermined whether the influence of social observation on placebo and nocebo effects to subsequent treatments remains even if related experience occurred a few days ago. Methods Eighty-two ...

Placebo and nocebo effects are embodied psycho-neurobiological responses capable of modulating pain and producing changes at different neurobiological, body at perceptual and cognitive levels. These modifications are triggered by different contextual factors (CFs) presented in the therapeutic encounter between patient and healthcare providers, such as healing rituals and signs. The CFs directly...

OBJECTIVE The objectives of the study were to determine the impact of nocebo effects on adverse events (AEs) in drug trials in fibromyalgia syndrome (FMS) and painful diabetic peripheral neuropathy (DPN). METHODS MEDLINE, CENTRAL, SCOPUS, and the databases of the U.S. National Institutes of Health and the Pharmaceutical Research and Manufacturers of America were searched until December 31, 20...