Pathogenic microorganisms have evolved sophisticated mechanisms to inactivate antibiotics and rendered an urgent need for new antibiotics that would target the emerging multidrug-resistance (Butler et al., 2013). Consequently, search for novel sources of potent antibiotics is desperately needed to develop potent drugs. Microbial resources have made an incredible contribution to the antibiotic d...

Monsanto’s Bt-cotton NC 33B, planted in northern China for more than one decade, effectively controls cotton bollworms; however the understanding of its potential effects on soil microorganisms is limited. The dynamics of eubacterial, fungal and actinomycetes population sizes in rhizosphere soil of the Bt cotton were analysed by realtime PCR (qPCR) at the different growth stages under field con...

Actinomycetes populate soils and aquatic sediments that impose biotic and abiotic challenges for their survival. As a result, actinomycetes metabolism and genomes have evolved to produce an overwhelming diversity of specialized molecules. Polyketides, non-ribosomal peptides, post-translationally modified peptides, lactams, and terpenes are well-known bioactive natural products with enormous ind...

conclusions the clinical klebsiella strains isolated from lahore region, pakistan exhibited resistance to most commonly used antibiotics, which can be a serious threat to public health. the study reported some potential actinomycetes strains, which exhibit promising activity against multidrug resistant klebsiella strains. results the isolated klebsiella strains showed resistance against most of...

conclusions preliminary results indicate that the native iranian actinobacteria could be considered a suitable option for screening of the new antibacterial compounds. molecular research and antibacterial compound extraction against the aforementioned pathogenic strains are also being conducted. results based on the morphological characterization, 35 isolated cases belonged to actinomycetes and...

conclusions this study showed that the collected soil from studied areas was rich of keratinophilic fungi and actinomycetes, therefore hygiene protocol should be taken to prevent the spread of pathogenic and saprophytes fungi in the environment of susceptible person. background keratinophilic fungi are a group of fungi that colonize in various keratinous substrates and degrade them to the compo...

Actinomycetes can be symbionts in diverse organisms, including both plants and animals. Some actinomycetes benefit their host by producing small molecule secondary metabolites; the resulting symbioses are often developmentally complex. Actinomycetes associated with three cone snails were studied. Cone snails are venomous tropical marine gastropods which have been extensively examined because of...

We tested 151 strains representing the genera Nocarclia and Gordma, the taxon ‘ Mycobacterium ’ rhodochrous and a collection of strains isolated from bagasse for their in vitro susceptibility to 52 antimicrobial agents by using the impregnated filter-paper disc method. The ‘ bagasse’ isolates were resistant to most of the antimicrobial agents but the nocardiae, gordonae and rhodochrous groups f...

Quinoxapeptin A and B are novel chromodepsipeptides which were isolated from a nocardioform actinomycete with indeterminant morphology. Quinoxapeptins A and B are potent inhibitors of HIV-1 and HIV-2 reverse transcriptase and almost equally active against two single mutants forms as well as a double mutant form of HIV-1 reverse transcriptase. Quinoxapeptin A and B are specific inhibitors of HIV...

Actinomycetes play an important role in the decomposition of various organic materials and replenish the supply of nutrients in the soil. They also produce many secondary metabolites possessing antimicrobial properties. The present study was conducted to determine the antibacterial and enzyme producing capabilities of soil Actinomycetes isolated from Nahargarh hill area, Jaipur, Rajasthan, Indi...