نتایج جستجو برای: no cgmp pathway

تعداد نتایج: 3568325  

Journal: :iranian journal of basic medical sciences 0
xu ziqiang transplantation center, the first affiliated hospital of wenzhou medical university, wenzhou, china wang jingjun transplantation center, the first affiliated hospital of wenzhou medical university, wenzhou, china zheng jianjian transplantation center, the first affiliated hospital of wenzhou medical university, wenzhou, china liang yong transplantation center, the first affiliated hospital of wenzhou medical university, wenzhou, china xia peng transplantation center, the first affiliated hospital of wenzhou medical university, wenzhou, china

objective(s): tadalafil can restore endothelial function and treat atherosclerosis. however, the effect of tadalafil on transplant arteriosclerosis remains unclear. in this study, we explore the effects of tadalafil on allograft vasculopathy. materials and methods: male brow-norway rats supplied aorta grafts for male lewis rats. all recipients were divided into 3 groups: saline as placebo (cont...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
H Y Yun M Gonzalez-Zulueta V L Dawson T M Dawson

N-methyl-D-aspartate (NMDA) glutamate receptor-mediated increases in intracellular calcium are thought to play a critical role in synaptic plasticity. The mechanisms by which changes in cytoplasmic calcium transmit the glutamate signal to the nucleus, which is ultimately important for long-lasting neuronal responses, are poorly understood. We show that NMDA receptor stimulation leads to activat...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1994
S L Archer J M Huang V Hampl D P Nelson P J Shultz E K Weir

Nitric oxide (NO)-induced relaxation is associated with increased levels of cGMP in vascular smooth muscle cells. However, the mechanism by which cGMP causes relaxation is unknown. This study tested the hypothesis that activation of Ca-sensitive K (KCa) channels, mediated by a cGMP-dependent protein kinase, is responsible for the relaxation occurring in response to cGMP. In rat pulmonary artery...

Journal: :Blood 2008
Vladan P Cokic Silvana A Andric Stanko S Stojilkovic Constance T Noguchi Alan N Schechter

Hydroxyurea, a drug widely used for treating myeloproliferative diseases, has also been approved for the treatment of sickle cell disease by raising fetal hemoglobin (HbF). We have shown that nitric oxide (NO) and the soluble guanylyl cyclase (sGC) pathways are involved in hydroxyurea induction of HbF levels in erythroid progenitor cells (EPCs). We demonstrate now that during erythroid differen...

Ali Shahraki, Marzieh Lotfian Sargazi, Ramin Saravani,

Background: This study aimed to investigate Levisticum officinale hydroalcoholic extract (LOHE) effect on both cGMP signaling pathway and phosphodiesterase 5 (PDE5) gene expression pattern and to examine the role of LOHE in apoptosis induction of MCF-7 and MDA-MB-468 cell lines. Methods: The half maximal inhibitory concentration (IC50) of LOHE was examined in both cell lines using the MTT assay...

Journal: :Molecular endocrinology 2007
Kate E Broderick Tong Zhang Hema Rangaswami Ying Zeng Xin Zhao Gerry R Boss Renate B Pilz

Natriuretic peptides and nitric oxide (NO) activate the cGMP/cGMP-dependent protein kinase (PKG) signaling pathway and play an important role in bone development and adult bone homeostasis. The cytokine IL-6 regulates bone turnover and osteoclast and osteoblast differentiation. We found that C-type natriuretic peptide and the NO donor Deta-NONOate induced IL-6 mRNA expression in primary human o...

2008
Vladan P. Cokic Silvana A. Andric Stanko S. Stojilkovic Constance T. Noguchi Alan N. Schechter

Hydroxyurea, a drug widely used for treating myeloproliferative diseases, has also been approved for the treatment of sickle cell disease by raising fetal hemoglobin (HbF). We have shown that nitric oxide (NO) and the soluble guanylyl cyclase (sGC) pathways are involved in hydroxyurea induction of HbF levels in erythroid progenitor cells (EPCs). We demonstrate now that during erythroid differen...

Journal: :Genes & development 1994
C Bowler H Yamagata G Neuhaus N H Chua

Three signal transduction pathways, dependent on cGMP and/or calcium, are utilized by phytochrome to control the expression of genes required for chloroplast development and anthocyanin biosynthesis in plant cells. For example, chs is controlled by a cGMP-dependent pathway, cab is controlled by a calcium-dependent pathway, and fnr is regulated by a pathway that requires both cGMP and calcium. U...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1996
N L Scholz M F Goy J W Truman K Graubard

In the neural circuits that comprise the crustacean stomatogastric nervous system (STNS), synaptically delivered neurotransmitters and circulating neurohormones elicit a wide range of rhythmic motor outputs. However, functional roles for second messengers in this system are poorly understood. Here we demonstrate two different signaling pathways that control the synthesis of 3',5'-cGMP in the cr...

Journal: :Pulmonary pharmacology & therapeutics 2014
Lisa L Dupont Constantinos Glynos Ken R Bracke Peter Brouckaert Guy G Brusselle

Nitric oxide (NO) is a gaseotransmitter, which is involved in many signaling processes in health and disease. Three enzymes generate NO from l-arginine, with citrulline formed as a by-product: neuronal NO synthase (nNOS or NOS1), endothelial NOS (eNOS or NOS3) and inducible NOS (iNOS or NOS2). NO is a ligand of soluble guanylyl cyclase (sGC), an intracellular heterodimer enzyme that catalyzes t...

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