nlrp7

Miguel A Fonseca-Sanchéz Carlos Pérez-Plasencia Jorge Fernández-Retana Elena Arechaga-Ocampo Laurence A Marchat Sergio Rodríguez-Cuevas Veronica Bautista-Piña Zaira E Arellano-Anaya Ali Flores-Pérez José Diaz-Chávez César López-Camarillo

microRNAs are small non-coding RNAs of ~22 nucleotides that function at post-transcriptional level as negative regulators of gene expression. Aberrant expression of microRNAs could promote uncontrolled proliferation, migration and invasion of human cancer cells. In this study, we analyzed the expression of microRNA-18b (miR-18b) in breast cancer cell lines and in a set of clinical specimens. Ou...

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Germline Mutation in NLRP2 (NALP2) in a Familial Imprinting Disorder (Beckwith-Wiedemann Syndrome)

Journal: :PLoS Genetics 2009

Esther Meyer Derek Lim Shanaz Pasha Louise J. Tee Fatimah Rahman John R. W. Yates C. Geoffrey Woods Wolf Reik Eamonn R. Maher

Beckwith-Wiedemann syndrome (BWS) is a fetal overgrowth and human imprinting disorder resulting from the deregulation of a number of genes, including IGF2 and CDKN1C, in the imprinted gene cluster on chromosome 11p15.5. Most cases are sporadic and result from epimutations at either of the two 11p15.5 imprinting centres (IC1 and IC2). However, rare familial cases may be associated with germline ...

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