background: recurrent spontaneous abortion (rsa) and in vitro fertilization (ivf) failure with unknown causes are the controversial issues that are probably related to the immune system. objective: to compare circulating nk cells expressing activation and inhibition surface markers between patients with rsa and ivf failure with those of healthy multiparous and successful ivf control women, resp...

behcet disease (bd) is a systemic inflammatory disease of the unknown etiology. there is however, some evidence to suggest that immunological abnormalities are important in its pathogenesis, furthermore several t-cell abnormalities which may be quite relevant to autoimmune origin of the disease have been described. we report here our study of t-cell subsets, b and nk cells in 68 patients with b...

The natural killer group 2D (NKG2D) is a transmembrane protein and a member of the CD94/NKG2 family of C-type lectin-like receptors. NKG2D is encoded by the KLRK1 gene, which is located in the NK-gene complex (NKC) placed on chromosomes 6 and 12 in mice and humans, respectively. NKG2D forms a homodimer structure and binds through ectodomains with its related ligands. Each of its monomers consis...

background: alteration in peripheral blood lymphocytes (pbls) is usually investigated to provide an evidence of the host immune responses to tumor antigens. the tumor infiltrating nk cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. objective: to analyze peripheral blood and tumor associated natural killer (nk) cells in patients with breast ca...

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, there are several limitations that need to be addressed target more types. Natural killer (NK) a type innate represent unique biology surveillance. In particular, NK obtained from heathy donors can s...

Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that capable killing virally infected and physiologically stressed cells, like tumor cells. In addition to their ability directly kill cancer NK enhancing both antibody T-cell responses. Moreover, ex vivo activation, expansion, genetic modification can greatly enhance anti-tumor activity equip them overcome resistan...

Herpesviruses are main sculptors of natural killer (NK) cell repertoires. While the ?-herpesvirus human cytomegalovirus (CMV) drives accumulation adaptive NKG2C-positive NK cells, ?-herpesvirus Epstein–Barr virus (EBV) expands early differentiated NKG2A-positive cells. cells support immunity by antibody-dependent cellular cytotoxicity, seem to preferentially target lytic EBV replicating B The i...

Currently, a large number of studies on genetic modification cord blood NK cells (UCB-NK) are carried out at both clinical and preclinical levels. Immunotherapy based UCB-NK has great potential for antitumor therapy. However, despite having known several advantages over peripheral (PB- NK), including high concentration in low virulence rate, predominantly characterized the scientific literature...

Increasing knowledge of cancer immunology has led to the design therapies using immune cells directly or manipulating their activity, collectively termed immunotherapy. In field immuno-oncology, research on adaptive T development CAR-T cells. Innate such as NK can also eliminate oncogenically transformed and regulate system. Considering a live drug, numerous methods for isolation activation hav...

Abstract Background: Cure rates for osteosarcoma (OS) have not improved in >30 years and no new effectivetherapies been identified metastatic disease. Natural killer (NK) cells become an attractive tool cancer immunotherapy. Efficay is by direct tumor targeting introducing a specific chimeric antigen receptor (CAR). Emerging knowledge suggests CD70 to be viable candidate as expression hi...