نتایج جستجو برای: nitroimidazole

تعداد نتایج: 662  

Journal: :Journal of general microbiology 1973
D I Edwards M Dye H Carne

Three antimicrobial nitroimidazole drugs (metronidazole, dimetridazole, and tinidazole) inhibit a range of clostridia and the protozoan Trichomonas vaginalis ; they have an identical site and mode of action as specific electron acceptors from the pyruvate phosphoroclastic reaction. Analogues of the drugs are compared and the structural requirements for activity explained. The nitrofuran (nitrof...

Journal: :Journal of Antimicrobial Chemotherapy 1997

Journal: :The Journal of antimicrobial chemotherapy 1997
M Castelli M Malagoli A I Ruberto A Baggio C Casolari C Cermelli M R Bossa T Rossi F Paolucci S Roffia

This paper reports the findings obtained using two new compounds belonging to the 5-nitroimidazole family: sulphuridazole (V1) and sulphonidazole (V2). We first assessed their antimicrobial activity on Clostridia spp. and then extended the study to Gram-positive and Gram-negative aerobic microorganisms and to Candida albicans. Their MICs were compared with those of metronidazole. The findings s...

Nitro-containing heteroaromatic derivatives structurally related to nitroimidazole (Metronidazole) are being extensively evaluated against Helicobacter pylori isolates. On the other hand, 1,3,4-thiadiazole derivatives have also demonstrated promising antibacterial potential. In present study, we evaluated anti-H. pylori activity of novel hybrid molecules bearing nitroaryl and 1,3,4-thiadiazole ...

Journal: :Molecules 2017
Fanny Mathias Youssef Kabri Liliane Okdah Carole Di Giorgio Jean-Marc Rolain Cédric Spitz Maxime D Crozet Patrice Vanelle

A one-pot regioselective bis-Suzuki-Miyaura or Suzuki-Miyaura/Sonogashira reaction on 2,4-dibromo-1-methyl-5-nitro-1H-imidazole under microwave heating was developed. This method is applicable to a wide range of (hetero)arylboronic acids and terminal alkynes. Additionally, this approach provides a simple and efficient way to synthesize 2,4-disubstituted 5-nitroimidazole derivatives with antibac...

2014
Eyal Meltzer Tamar Lachish Eli Schwartz

During January 2008-October 2013, a total of 12 cases of giardiasis at the Chaim Sheba and Shaare Zedek Medical Centers, Israel, did not respond to nitroimidazole; 83.3% were associated with travel and 33% with immunoglobulin deficiency. Among 110 published cases, the most effective treatment was quinacrine (efficacy 90%-100%), but its availability is limited.

Journal: :Antimicrobial Agents and Chemotherapy 1986

Journal: :International Research Journal Of Pharmacy 2018

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