Isothiazolones and 5-chloroisothiazolones react chemoselectively with thiols by cleavage of the weak nitrogen-sulfur bond to form disulfides. They show selectivity for inhibition of the thiol-dependent cysteine protease cathepsin B and the histone acetyltransferase p300/CBP associated factor (PCAF) based on their substitution pattern. Furthermore, enzyme kinetics and mass spectroscopy indicate ...

Electrochemical CO2 reduction presents a sustainable route to the production of chemicals and fuels. Achieving narrow product distribution with heterogeneous Cu catalysts is challenging conventional material modifications offer limited control over selectivity. Here, we show that surface-immobilised molecular species can act as inhibitors for specific carbon products provide rational distributi...

Food selection behaviour, food utilization efficiency and growth performance of a generalist insect, the gypsy moth (Lyrnantria dispar (L.), Lepidoptera: Lymantriidae), were examined with respect to variation in food nitrogen concentration. The results suggest that gypsy moth do not suffer physiologically and in fact -may benefit from intraplant variation by selective feeding. When provided wit...

The development of highly stable and efficient electrocatalysts for sluggish oxygen reduction reaction (ORR) is exceedingly significant for the commercialization of fuel cells but remains a challenge. We here synthesize a new nitrogen-doped biocarbon composite material (N-BC@CNP-900) as a nitrogen-containing carbon-based electrocatalyst for the ORR via facile all-solid-state multi-step pyrolysi...

Porous carbon monoliths with defined multilength scale pore structures, a nitrogen-containing framework, and high mechanical strength were synthesized through a self-assembly of poly(benzoxazine-co-resol) and a carbonization process. Importantly, this synthesis can be easily scaled up to prepare carbon monoliths with identical pore structures. By controlling the reaction conditions, porous carb...

Nitrogen heterocycles represent vital structural motifs in biologically-active natural products and pharmaceuticals. As a result, the development of new, convenient and more efficient processes to N-heterocycles is of great interest to synthetic chemists. Samarium(II) iodide (SmI₂, Kagan's reagent) has been widely used to forge challenging C-C bonds through reductive coupling reactions. Histori...

A novel strategy to graft functional groups at the surface of carbon nanotubes (CNTs) is discussed. Aiming at grafting nitrogen containing groups, and more specifically primary amine covalent functionalization, CNTs were exposed under atomic nitrogen flow arising from an Ar + N2 microwave plasma. The primary amine functions were identified and quantified through chemical derivatization with 4-(...

the conversion process of heavy hydrocarbons to the valuable products such as gasoline is an important operation in the oil refineries.one important process is the “fluidized catalytic cracking” (fcc).feed injection in fcc process has an important role in the selectivity and properties of the products.performance of the feed injection system is dependent on the atomizers.the size and contributi...

Au(I) complexes catalyze iso-Pictet–Spengler reactions. Ethylamine or methylamine chains were introduced at C2, C4, the nitrogen atom of indole ring, and corresponding substrates reacted in presence aldehydes catalytic amounts complexes, leading to a variety polycyclic scaffolds. Selectivity could be achieved course double reaction involving two successive aldehydes, highly complex molecules.

RebH variants capable of chlorinating substituted indoles ortho-, meta-, and para- to the indole nitrogen were evolved by directly screening for altered selectivity on deuterium-substituted probe substrates using mass spectrometry. This systematic approach allowed for rapid accumulation of beneficial mutations using simple adaptive walks and should prove generally useful for altering and optimi...