OBJECTIVE To evaluate the antimicrobial susceptibility of Gram-negative uropathogens isolated from pregnant women. METHODS We performed a snapshot cohort study of women receiving care in the University of Florida prenatal clinics during March 2000. Subjects with asymptomatic bacteriuria or cystitis were identified and the antimicrobial susceptibility of each pathogen was recorded. Data were a...

A study was carried out comparing the reporting of adverse reactions to nitrofurantoin in Sweden, Holland, and the United Kingdom. The Swedish drug regulatory authorities receive more reports of adverse reactions to nitrofurantoin than to any other drug, and the annual reporting rate is increasing despite a steady fall in the prescription of nitrofurantoin. In the United Kingdom the total numbe...

background enterococcus faecium is an important nosocomial pathogen and has developed resistance to multiple antibiotics, such as vancomycin. nitrofurantoin is active against e. faecium and e. faecalis, including vana- and vanb-positive isolates. objectives to investigate the role of rpob mutation in e. faecium. methods the growth rate and reactive oxygen species (ros) levels were determined. t...

BACKGROUND The antibiotic nitrofurantoin is commonly used to treat uncomplicated urinary tract infections. However, when this drug is used by patients with reduced kidney function, its urine concentration may be subtherapeutic. METHODS We conducted a population-based study of older women (mean age 79 years) in Ontario, Canada, whose estimated glomerular filtration rate was relatively low (med...

An increase in extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli has been observed in outpatient settings. Consequently, 100 ESBL-positive E. coli isolates from ambulatory patients with clinically confirmed urinary tract infections were collected by a single laboratory between October 2004 and January 2008. Antimicrobial susceptibility testing was carried out using the oral ant...

The high urinary drug concentrations usually encountered after administering nitrofurantoin in the chemotherapy of urinary tract infections are often measured by the nitromethane-Hyamine method. We show here that, if the urinary tract analgesic, phenazopyridine hydrochloride, and its related metabolite(s) are in the urine, they interfere with this determination of nitrofura ntoin. Nevertheless,...

Nitrofurantoin is a drug commonly used for urinary tract infections. It acts by damaging bacterial DNA. It is given in dose of 50-100 mg orally and is generally considered a safe drug but has occasionally been known to cause pulmonary toxicity which is usually reversible and only rarely fatal. We present a case of an elderly lady receiving nitrofurantoin for her urinary tract infection who deve...

Abstract Background Nitrofurantoin is a preferred empiric antibiotic for the treatment of acute cystitis; however, there are limited data on nitrofurantoin utilization patterns and bacterial resistance in outpatient setting. The objectives this study were to describe use an integrated health system evaluate resistance. Methods A retrospective review patients prescribed at Denver Health from Jan...