Cancer is a multifactorial disease and hence can be effectively overcome by a multi-constituently therapeutic strategy. Medicinal plant extracts represent a perfect example of such stratagem. However, minimal studies have been done till date that portray the effect of extraction techniques on the phyto-constituent profile of plant extracts and its impact on anticancer activity. In the present s...

Induced protein degradation accomplishes elimination, rather than inhibition, of pathological proteins. Key to the success this novel therapeutic modality is modification proteins with ubiquitin chains, which brought about by molecular glues or bivalent compounds that induce proximity between target and an E3 ligase. The human genome encodes ?600 ligases differ widely in their structures, catal...

NanomedicineVol. 16, No. 16 CommentaryOpen AccessAdvances in nanotechnology-based drug delivery targeting PI3K signaling respiratory diseasesYinghan Chan, Ronan MacLoughlin, Flavia C Zacconi, Murtaza M Tambuwala, Ritesh Pabari, Sachin Kumar Singh, Terezinha de Jesus Andreoli Pinto, Gaurav Gupta, Dinesh Chellappan & Kamal DuaYinghan Chan https://orcid.org/0000-0001-8405-8637School of Pharmacy, I...

Nature takes advantage of induced proximity to perform various functions. Taking inspiration from nature, we can also trigger desired biological processes using bifunctional small molecules that artificially induce proximity. For example, have been designed the ubiquitin-dependent proteasomal degradation intracellular proteins. Now, recent classes compounds developed degrade extracellular targe...