The mechanisms that control organelle size are poorly understood. Genetic analysis now shows that a NIMA-related kinase helps to regulate the size of cilia by activating disassembly of the cilium when it gets too long.

in this paper a comparative analysis of two poems entitled â« phoenix â» by nima and â«l’albatros â» by baudelaire will be done. it, initially, tries to investigate the symbolism used by these two poets. then a comparative analysis is made from structural and thematic points of view. by comparing and contrasting the potential similarities and differences in these poems, an attempt is made to ...

A new study shows that phospho-dependent expulsion of type-1-phosphatase (PP1) from the spindle pole by Fin1 (NIMA) kinase ensures switch-like activation of Cyclin B-Cdk1 at the G2/M transition.

Nek2, a mammalian protein kinase of unknown function, is closely related to the mitotic regulator NIMA of Aspergillus nidulans. Here we show by both immunofluorescence microscopy and biochemical fractionation that human Nek2 localizes to the centrosome. Centrosome association occurs throughout the cell cycle, including all stages of mitosis, and is independent of microtubules. Overexpression of...

The NIMA-related kinase 2 (NEK 2) has important cell cycle functions related to centriole integrity and splitting. Trypanosoma brucei does not possess centrioles, however, cytokinesis is coupled to basal body separation events. Here we report the first functional characterisation of a T. brucei basal body-cytoskeletal NIMA-related kinase (NRK) protein, TbNRKC. The TbNRKC kinase domain has high ...

This paper addresses testing issues associated with System-on-Chip (SoC) designs. A network-processing engine SoC was constructed using reusable Intellectual Property (IP) and a test harness based on the emerging IEEE P1500 standard. Three different test access mechanisms (TAMs) are compared on this platform – a serial threading approach analogous to the IEEE1149.1 standard, a test-rail approac...

The NIMA-family kinases Nek9/Nercc1, Nek6 and Nek7 form a signalling module required for mitotic spindle assembly. Nek9, the upstream kinase, is activated during prophase at centrosomes although the details of this have remained elusive. We now identify Plk1 as Nek9 direct activator and propose a two-step activation mechanism that involves Nek9 sequential phosphorylation by CDK1 and Plk1. Furth...