Free radical formation in the cochlea plays a key role in the development of noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant formation of both reactive oxygen species and reactive nitrogen species 7-10 days after noise exposure. Reduction in cochlear blood flow as a result of free radica...

BACKGROUND Excessive noise is a global occupational health hazard with considerable social and physiological impacts, including noise-induced hearing loss (NIHL). This paper describes the worldwide morbidity of occupational NIHL in the year 2000. METHODS The proportion of the population exposed to occupational noise was estimated using noise exposure data from the US National Institute for Oc...

Work-related noise exposure is one of the major factors contributing to the development of adult-onset hearing loss and tinnitus. The aim of this study was to analyze, in patients with chronic tinnitus and long-term occupational noise exposure, (A) characteristics of hearing loss, tinnitus, comorbidities, demographic characteristics and a history of work-related noise exposure and (B) differenc...

Noise-induced hearing loss (NIHL) is an important occupational disease worldwide resulting from interactions between genetic and environmental factors. The purpose of this study was to examine whether genetic variations in POU4F3 and GRHL2 may influence susceptibility to NIHL in the Chinese population. A matched case-control study was carried out among 293 hearing loss individuals and 293 norma...

OBJECTIVES Noise-induced hearing loss (NIHL) is costly in both human and economic terms. One means of reducing NIHL is to apply engineering controls to hazardous noise sources. To trade off the cost of engineering controls against the total direct monetary costs incurred by NIHL, a means of predicting the amount of NIHL that will be incurred over the life-cycle of a hazardous noise source is ne...

Introduction  Noise-induced hearing loss (NIHL), which is one of the most common occupational diseases among industrialized populations, is associated with longstanding exposure to high levels of noise. The pathogenesis of NIHL is not clear, but some genes and their activity at the tissue level have been investigated. Hypercholesterolemia, which can disturb the microcirculation, can be one of t...

Exposure to intense sound or noise can result in purely temporary threshold shift (TTS), or leave a residual permanent threshold shift (PTS) along with alterations in growth functions of auditory nerve output. Recent research has revealed a number of mechanisms that contribute to noise-induced hearing loss (NIHL). The principle cause of NIHL is damage to cochlear hair cells and associated synap...

BACKGROUND Noise is the most common occupational hazard. Noise-induced hearing loss (NIHL) is a known occupational disease. The economic costs of NIHL have been estimated to be billions of dollars. Besides, cigarette smoking is a common habit worldwide. METHODS In a cross-sectional study, we surveyed the effect of smoking on NIHL in 504 workers in a large wagon manufacturing company exposed t...

OBJECTIVE Our objective was to analyze the electrocochleography (ECoG) and cervical vestibular evoked myogenic potential (cVEMP) results of patients with noise-induced hearing loss (NIHL). MATERIALS AND METHODS The study included 20 patients with NIHL. Pure-tone audiometry, tympanic membrane ECoG, and cVEMP were performed on all patients. The patients were divided into two groups based on ave...

OBJECTIVE The purpose of this study was to investigate the effects of noise exposure on the cervical vestibular evoked myogenic potential (cVEMP) in individuals with asymmetric noise-induced sensorineural hearing loss (NIHL). DESIGN A cross-sectional observational study was used to compare cVEMP characteristics in 43 individuals with a history of noise exposure greater in one ear (e.g., the l...