The medicinal plants have attracted great attention in the recent years for better therapeutic management of diseases. Nigella sativa is one of the most extensively studied plants and has gained more and more interest for potential medical use in recent years. Historical and traditional uses of this herb have been widely documented in ancient documents; and Nigella sativa have been broadly used...

background: despite availability and administration of numerous antiepileptic drugs (aeds) nearly 15% of childhood epilepsy cases are resistant to treatment; in traditional medicine however nigella sativa l. (black seed) has been known for its anticonvulsant effects. materials and methods: in this double-blind clinical trial conducted on children with refractory epilepsy we administered the aqu...

A recent study in 2019-2020 assessed the productivity, quality of fatty and essential oils, mineral composition eight nigella genotypes at Federal State Budget Scientific Institution (FSBSI), Research Institute Agriculture Crimea, Simferopol, Russia. Of genotypes, two cultivars originated from Russia (Nigella sativa cv. ‘Krymchanka,’ Nigella damascena ‘Yalita’), one each six European-Asian coun...

Nigella sativa L. (Ranunculaceae) seeds (black cumin) that contain high oil, terpene, protein, alkaloids are an economically important for medicine and food industry. Lack of an efficient DNA isolation procedure is a limiting factor for any molecular studies of these plant. We have used a genomic DNA isolation protocol for Nigella sativa seeds based on a hexadecyltrimethylammonium bromide (CTAB...

The present study was designed to investigate some histopathological changes produced by cimetidine on male reproductive organs (testes & epididymis) in mice and extended to examine wherethere using of aqueous suspension of powdered Nigella sativa seeds have ability to reduce this toxicity.Forty male mice were divided into 4 groups. The first group received 25 mg/kg B.W. of cimetidine orally on...

Nigella sativa is an important spice and flavoring agent which is widely used in various European and Asian cuisines. It harbors an array of medicinal properties as shown by various researches. Germination is a phenomenon during which rapid changes in metabolic activities and the interconversions of metabolites take place. The objective of present study was to evaluate the antibacterial activit...

Objective: Oxidative stress plays an important role in the etiology of diabetic complications. Diabetes impairs hippocampus neurogenesis, synaptic plasticity, and learning. The aim of this study was to investigate the effects of hydroalcoholic extract of Nigella sativa seed on oxidative stress in STZ-induced diabetic rats' hippocampus. Materials and Methods: Diabetes induced by 60 mg/kg STZ, i....

The interplay of processes in central and specialized metabolisms during seed development of Nigella sativa L. was studied by using a high-throughput metabolomics technology and network-based analysis. Two major metabolic shifts were identified during seed development: the first was characterized by the accumulation of storage lipids (estimated as total fatty acids) and N-compounds, and the sec...