Autoimmune hemolytic anemia (AIHA) is a collective term for several diseases characterized by autoantibody-initiated destruction of red blood cells (RBCs). Exact subclassification is essential. We provide a review of the respective types of AIHA with emphasis on mechanisms of RBC destruction, focusing in particular on complement involvement. Complement activation plays a definitive but limited ...

The association between autoimmune hemolytic anemia (AIHA) and subsequent appearance of lymphoproliferative disorders (LPDs) has not been properly addressed in large-scale studies. We evaluated 107 patients with idiopathic (67 patients) or underlying (40 patients) immune disorders diagnosed with AIHA between 1992 and 1999. The following variables were examined in univariate and multivariate ana...

1例目は71歳，女性．動悸を主訴に当科を紹介受診した．血色素7.7 g/dl，ハプトグロビン10 mg/dl以下，Coombs試験陽性から自己免疫性溶血性貧血（AIHA）と診断された．プレドニゾロン（prednisolone，PSL）投与が著効したが，AIHAの診断後1年8カ月経過した頃よりALP，γGTPの上昇ならびに抗ミトコンドリアM2抗体の高値を示し，肝組織検査で中沼分類stage 2の原発性胆汁性胆管炎（PBC）と診断された．2例目は67歳，男性．褐色尿を主訴に当科を紹介受診した．血色素が10.3 g/dl，ハプトグロビンが10 mg/dl以下，Coombs試験が陽性であり，AIHAと診断された．1例目同様にPSLが著効したが，初診時からの持続的なALP，γGTPの上昇ならびに抗ミトコンドリアM2抗体の高値を示し，肝組織検査で中沼分類stage 2のPBCと診断された．2症例...

​A anemia hemolítica autoimune (AIHA) é uma doença incomum, em que ocorre a destruição de hemácias mediada por autoanticorpos do hospedeiro, sendo sua patogênese ainda pouco esclarecida. O presente estudo descreve um caso mulher 45 anos com idiopática clínica sugestiva mediação anticorpos quentes (w-AIHA) e laboratório confirmatório aglutinina fria (DAC). Observou-se história comum às anemias h...

none of the available drugs are able to stop severe hemolysis immediately [4]. In view of these facts, each newly diagnosed ‘AIHA’ may become a challenging experience for the doctor who is responsible for the patient for several reasons: i) There is no close relationship between the laboratory findings and the clinical symptoms of the patient. ii) Hypoxic anemia may require urgent transfusion. ...

abstract to study the efficacy of glyphosate and nicosulfuron herbicides on barnyardgrass [echinochloa crus-galii (l.) p. beauv.] and velvetleaf (abotilon theophrasti medicus.) control and to find the ed50 index, experiments were conducted as factorial arrangement of treatments 2×7 based on completely randomized design with six replications for each weed in 2008-9 at research greenhouse, ferdow...

INTRODUCTION Unlike autoimmune hemolytic anemia (AIHA), literature on the etiological study of non-autoimmune hemolytic anemia (non-AIHA) is scarce. The incidence and prevalence of non-AIHA in different geographic regions are largely unknown perhaps owing to the lack of perspective investigation and different profiles of etiologies from different geographic regions. We aimed to examine the real...

The ovarian cystic teratoma is a rare cause of autoimmune haemolytic anaemia by warm antibodies, resistant to corticotherapy, with few case reports published in the medical literature. We present a case of a 45-year-old woman admitted to hospital due to general weakness. Laboratory studies revealed macrocytic anaemia, biochemical parameters of haemolysis and peripheral spherocytosis. The direct...

Autoimmune hemolytic anemia (AIHA) is a heterogeneous and relatively unknown disease caused by premature immune destruction of red blood cells. While its occurrence is uncommon among children, it is sometimes severe and resistant to treatment. The warm-reactive type contains 70% to 80% of all cases, in which the first-line treatment is considered to be a steroid. Moreover, splenectomy, rituxima...

BACKGROUND Autoimmune hemolytic anemia (AIHA) is a less recognized, potentially fatal condition. There is a scarcity of data on clinicoserological characteristics and response to therapy concerning this disease from South India. METHODS Data for 33 patients with primary AIHA recorded from July 2009 to June 2015 were retrospectively analyzed for clinical presentation, response to frontline the...