Nicolau syndrome is a rare adverse reaction to a variety of intra-muscular drug preparations. The typical presentation is pain around the injection site soon after injection, followed by erythema, livedoid patch, hemorrhagic patch, and finally, necrosis of skin, subcutaneous fat, and muscle tissue. The phenomenon has been related to the administration of a variety of drugs, including non-steroi...

Nicolau syndrome (NS) is a rare complication of intramuscular, intraarticular or subcutaneous injection of particular drugs leading to ischemic necrosis of the surrounding skin, soft tissue and muscular tissue. Benzathine penicilin one of the most widely used antibiotic for upper respiratory tract infections and has been rarely reported to cause NS. Here we describe a 4 year old boy with diagno...

Claudia M. Denkinger, Ioana Nicolau, Andrew Ramsay, Pamela Chedore and Madhukar Pai Division of Infectious Disease, Beth Israel Deaconess Medical Center, Boston, MA, USA. McGill International TB Centre and Dept of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, and Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Montreal, Mon...

Giant and Calcified Post-Infarction True Left Ventricular Aneurysm: What to Do? Alexandre Hideo Kajita*, Marcos Danillo Peixoto Oliveira*, Fernando Reis Menezes, Marcelo Franken, Luciano Moreira Baraciolli, José Carlos Nicolau Instituto do Coração – Universidade de São Paulo, São Paulo, SP – Brazil *The authors Alexandre Hideo Kajita and Marcos Danillo Peixoto Oliveira have contributed equally ...