Metal complex of pioglitazone hydrochloride (PLZ) drug with Ni(II) ion is synthesized and characterized using analytical data, molar conductance, IR, UV-Vis, magnetic, mass spectral and XRD studies. From the analytical data, the complex is proposed to have general formula [(C 19 H 19 N 2 O 3 S)+ 2 Ni]2Cl-. The conductometric titration using monovariation method reveals that complex is L 2 M typ...

The title complex, [Ni(II)(C(2)H(8)N(2))(3)](2)[Mo(IV)(CN)(8)]·2H(2)O, crystallized from a mixture of ethane-1,2-diamine (en), octa-cyano-molybdate(IV), [Mo(CN)(8)](4-), and the transition metal ion Ni(2+). In the crystal structure, the Mo polyhedron has a square-anti-prismatic shape, while the geometry around the Ni atom is distorted octa-hedral. The complex ions and water mol-ecules are linke...

A tripod ligand tris(N-methylbenzimidazol-2-ylmethyl)amine (Mentb) and its nickel(II) picrate (pic) complex, with composition [Ni(Mentb)(DMF)(H2O)](pic)2, have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, and UV/Vis measurements. Single-crystal X-ray diffraction revealed that the Ni atom is six-coordinated in a distorted octahedral geo...

Two new organic hybrid thiogermanates [Ni(dien)2](H2dien)Ge2S6 (1, dien = diethylenetriamine) and [Ni(teta)2]2Ge4S10 (2, teta = triethylenetetramine) were synthesized under solvothermal conditions. 1 contains a [Ni(dien)2] complex cation, a protonated dien molecule and a [Ge2S6]4− dimeric anion, while 2 consists of discrete [Ge4S10]4− adamantane-like cluster anions with [Ni(teta)2] complex cati...

Administration of nickel carbonyl to rats inhibited RNA synthesis by a chromatin-RNA polymerase complex prepared from lysed hepatic nuclei. Rats were killed 6 hr after i.v. administration of Ni(CO)4 in LDSO dosage (2.2 mg Ni/100 g body weight). The rate of RNA synthesis by the chromatinRNA polymerase complex from Ni(CO)4-treated rats averaged 0.16 (S.E. = ±0.02, N = 18) ¿/mole cytidine tripho...

A Ni(ii) complex with two t-butylisocyanide ligands supported by a N3C(-) type tetradentate ligand was synthesized and characterized. Quantitative generation of the aromatic cyanation product, (tBu)N3C-CN, is observed by reacting this Ni(ii) complex with 1 equiv. of an oxidant. Reactivity studies suggest that this oxidatively-induced cyanation involves a heterolytic cleavage of the N-(t)Bu bond...

The title mononuclear Ni(II) complex, [Ni(C(11)H(11)N(2)O(5))(2)(C(2)H(8)N(2))(2)], is built up by inversion symmetry associated with the central Ni atom. The ethyl-enediamine ligands are non-planar. The r.m.s. deviation from the mean plane of the five-membered Ni-ethyl-amine chelate ring plane is 0.1945 Å. In the crystal structure, complex mol-ecules are linked to each other via N-H⋯O and O--H...

In the title salt, (C2H8N)2[Ni(H2O)6)](SO4)2·2H2O, the Ni(II) cation is located on a centre of inversion and exhibits a slightly distorted octa-hedral arrangement of water mol-ecules. The Ni-O bond lengths in the complex [Ni(H2O)6](2+) cation show a distribution as in the related Tutton salt (NH4)2[Ni(H2O)6](SO4)2, but are longer in average [2.056 (13) versus 2.037 (12) Å]. The noncoordinating ...

The imido complex (dtbpe)Ni(N(2,6-(CHMe2)2C6H3)) reacts with CO and CNCH2Ph with addition at the Ni-N bond to give (dtbpe)Ni(C,N:eta 2-C(O)N(2,6-(CHMe2)2C6H3)) and (dtbpe)Ni(C,N:eta 2-C(NCH2Ph)N(2,6-(CHMe2)2C6H3)); both complexes react further with CO to liberate the isocyanate and carbodiimide ligands with formation of (dtbpe)Ni(CO)2.

BACKGROUND NI-0401 is a fully human monoclonal antibody, which binds to the CD3 subunit of the T-cell receptor, causing modulation of T-cell activity. We investigated the safety and the ability to modulate the TCR-CD3 complex of NI-0401 in patients with active Crohn's disease (CD). METHODS A double-blind, placebo-controlled, randomized, multicenter, dose-escalating trial was conducted in CD p...