NHK STRL 10 Speech synthesis is a very convenient means of conveying spoken information without the need for human labor. The most commonly used method of speech synthesis in program production compiles speech recorded during different tasks. Additionally, the textto-speech (TTS) synthesis, which can synthesize speech from any text, can be used to deal with dialogue spoken with unemotional or u...

Closed captioning to convey the speech of TV programs by text is becoming a useful means of providing information for elderly people and the hearing impaired, and real-time captioning of live programs is expanding yearly thanks to the use of speech recognition technology and special keyboards for high-speed input. This paper describes the current state of closed captioning, provides an overview...

Inorganic arsenic is a major environmental contaminant associated with an increased risk of human skin cancer. Arsenic modulates cellular signaling pathways that affect diverse processes such as cell proliferation, differentiation, and apoptosis, including genotoxic damage. The p53 protein plays a central role in mediating stress and DNA damage responses, leading to either growth arrest or apop...

BACKGROUND alpha-Dystroglycan (alpha-DG) is a negatively charged glycoprotein that covers the surface of podocytes. A decreased glomerular expression of alpha-DG has been described in minimal change nephropathy (MCN), but not in focal segmental glomerulosclerosis (FSGS). This was suggested as a tool to distinguish these diseases. Sialic acid is a negatively charged carbohydrate extensively pres...

When a protein misfolds in the endoplasmic reticulum (ER), it retrotranslocates to the cytosol and is degraded by the proteasome via a pathway called ER-associated degradation (ERAD). To initiate ERAD, ADP-BiP is often recruited to the misfolded client, rendering it soluble and translocation competent. How the misfolded client is subsequently released from BiP so that it undergoes retrotransloc...

In recent work, Sadakane and Grossi [SODA 2006] introduced a scheme to represent any sequence S = s1s2 . . . sn, over an alphabet of size σ, using nHk(S) +O( n logσ n (k log σ + log log n)) bits of space, where Hk(S) is the k-th order empirical entropy of S. The representation permits extracting any substring of size Θ(log σ n) in constant time, and thus it completely replaces S under the RAM m...

A succinct full-text self-index is a data structure built on a text T = t1t2 . . . tn, which takes little space (ideally close to that of the compressed text), permits efficient search for the occurrences of a pattern P = p1p2 . . . pm in T , and is able to reproduce any text substring, so the self-index replaces the text. Several remarkable self-indexes have been developed in recent years. The...

Hikikomori is one of the most common social problems in Japan. This research's object anime series NHK ni Youkoso !, with 24 episodes, which premiered from July to December 2006. The author uses observation method note-taking techniques collect data, and data analysis written descriptively. results this study contained 11 forms behaviour that studied, namely: hikikomori perpetrators confined th...

Protein folding in the endoplasmic reticulum (ER) is error prone, and ER quality control (ERQC) processes ensure that only correctly folded proteins are exported from the ER. Glycoproteins can be retained in the ER by ERQC, and this retention contributes to multiple human diseases, termed ER storage diseases. UDP-glucose:glycoprotein glucosyltransferase (UGGT1) acts as a central component of gl...