The differentiation of T helper cells into distinct functional subtypes is critical for mediating effective adaptive immune responses. The molecular mechanism by which a Th precursor cell (Thp) adopts a Th1 or Th2 phenotype involves a complex interplay between the induction of lineagespecific transcription factors, such as T-bet, Gata3, and c-Maf, and the stimulatory effects of the cytokine mil...

CD40 is a critical stimulatory receptor on antigen-presenting cells of the immune system. CD40-mediated activation of B cells is particularly important for normal humoral immune function. Engagement of CD40 by its ligand, CD154, on the surface of activated T cells initiates a variety of signals in B cells including the activation of MAP kinases and NF-κB. The transcriptional regulator NF-κB is ...

Abstract The atypical IκB family member Bcl3 associates with p50/NF-κB1 or p52/NF-κB2 homodimers in the nucleus, and positively negatively modulates transcription a context-dependent manner. Since expression dendritic cells (DC) is pivotal for antigen presentation since classical DCs (cDC) are major presenting cells, we investigated role of specifically cDCs vivo by crossing Zbtb46 cre mice Bcl...

Signaling by hormonal vitamin D, 1,25-dihydroxyvitamin D (1,25D) has attracted increasing interest because of its non-classical actions, particularly its putative anticancer properties and its role in controlling immune system function. Notably, the hormone-bound vitamin D receptor (VDR) suppresses signaling by pro-inflammatory NF-κB transcription factors, although the underlying mechanisms hav...

Proteins from underutilized defatted oilseed meals have been proposed as promising sources of bioactive peptides. This study was conducted to determine the anti-inflammatory activities five proteins (flaxseed, rapeseed, sunflower, sesame and soybean) hydrolysed via alcalase, pepsin (at pH 1.3 2.1), respectively, compare these against two dairy (whey, casein). The potential protein hydrolysates ...