Spontaneous periodic breathing, although a common feature in fullterm and preterm human infants, is scarce in other newborn mammals. The aim of this study was to induce periodic breathing in lambs. Four 10-day-old and two <48-h-old awake lambs were instrumented with jugular catheters connected to an extracorporeal membrane lung aimed at controlling arterial PCO2 (PaCO2). Arterial PO2 (PaO2) was...

Tichy F.: The ultrastructure of Taste Buds in the Newborn Lamb. Acta vet. Brno, 61, 1992: 83-91. The ultrastructure of taste buds on circumvallate papillae collected from the tongues of three lambs on the day of birth was studied. Of special concern were the composition of the bud from dark, light and receptor cells, formation of the taste pore and the presence and nature of contacts of intrage...

Bradykinin is a potent constrictor of the human umbilical artery and vein and the ductus arteriosus of the lamb in vitro at oxygen tensions above 40 mm Hg (comparable to those in the newborn infant). Bradykinin is also capable of producing remarkable dilatation of the pulmonary vasculature of the lamb. Theoretically, kinins are capable of effecting some of the rapid circulatory changes required...

Although superiority of synthetic surfactant over animal-driven surfactant has been known, there is no synthetic surfactant commercially available at present. Many trials have been made to develop synthetic surfactant comparable in function to animal-driven surfactant. The efficacy of treatment with a new synthetic surfactant (CHF5633) containing dipalmitoylphosphatidylcholine, phosphatidylglyc...

The exact time of functional closure of the ductus arteriosus in the newborn human infant has remained a matter of speculation for many years. Studies of human anatomical specimens have shown that complete morphologic closure requires from four to eight weeks (1-5). Animal experiments have been the main approach to the study of functional closure. All workers agree that at the time of birth, bu...

BACKGROUND Colostrum intake by newborn lambs plays a fundamental role in the perinatal period, ensuring lamb survival. In this study, blood plasma samples from two groups of newborn lambs (Colostrum group and Delayed Colostrum group) at 2 and 14 h after birth were treated to reduce the content of high abundance proteins and analyzed using Two-Dimensional Differential in Gel Electrophoresis and ...

Newborn lambs (n = 45) at the Agricultural Research Institute of Northern Ireland were fed either 50 grams of commercial lamb milk replacer or 50 grams of commercial colostrum replacer (bovine origin) in 200 ml of water four times during the first 24 hours of life or were given ad libitum access to the ewe. Total plasma protein at 24 hours of age was highest in lambs allowed to suckle the ewe (...

To test the hypothesis that the rise in arterial pressure occurring with maturation is due to an increase in the vascular responsiveness to angiotensin II, sequential cumulative doses of angiotensin II were infused intravenously into chronically catheterized newborn lambs maintained on a constant, weight-adjusted sodium intake from birth to 8 weeks of age. Basal mean arterial pressure correlate...