Traumatic brain injury (TBI) remains a highly lethal injury with mortality ranging from 20-50 percent (Bulger et al., 2002; Demetriades et al., 2004; Jiang et al., 2002). Approximately 52,000 patients die from TBI each year (Sosin et al., 1995; Thurman et al., 1999) with approximately 85 percent of the deaths occurring within the first two weeks (Roberts et al., 2004). TBI pharmaceutical trials...