In the prescriptions of an endocrinologist to patients with diabetes mellitus, glucagon-like peptide agonists, belonging group that affects incretin system body, have recently been increasingly appearing. addition pronounced hypoglycemic effect and high safety, these drugs also many pleiotropic properties due presence receptors in vascular endothelium, kidneys, heart nervous tissue. The purpose...

objective(s) previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-tct) can reduce ischemic damage in mice following middle cerebral artery (mca) occlusion. it is also reported to decrease stroke- dependent brain tissue damage in 12-lox-deficient mice and spontaneously hypertensive rats. in the present study, the neuroprotective effects of a-tct and rosiglitazone (rgz) ...

Switching microglia from a disease exacerbating, ‘pro-inflammatory’ state into neuroprotective, ‘anti-inflammatory’ phenotype is promising strategy for addressing multiple neurodegenerative diseases.

Pramipexole (PPX) is a full intrinsic activity, direct-acting dopamine (DA) agonist possessing 7-fold higher affinity for D3 than for D2 receptors. It also is a potent antioxidant. PPX was previously shown to be neuroprotective because it dose dependently attenuated the DA neuron loss produced by levodopa in mesencephalic cultures. Several different drugs with properties similar to PPX were stu...

The plethora of failed clinical trials with neuroprotective drugs for acute ischemic stroke have raised justifiable concerns about how best to proceed for the future development of such interventions. Preclinical testing of neuroprotective drugs is an important aspect of assessing their therapeutic potential, but guidelines concerning how to perform preclinical development of purported neuropro...