Acardiac twinning is a very rare complication of multiple pregnancy. The authors present the neuropathological and anatomopathological description of the twins of the multiple pregnancy complicated by the acardiac foetus and terminated at 26 weeks of gestation. An anatomopathological examination of the "normal" twin showed hyaline membrane syndrome, cardiomegaly and hepatomegaly. Neuropathologi...

BACKGROUND Neuropathological data are very scarce in systemic sclerosis and fail to demonstrate primary changes in the brains of such patients. CASE DESCRIPTIONS A 41-year-old woman with CREST syndrome developed signs of dementia after an episode of severe dehydration and died two months later of septic shock. A 63-year-old woman with CREST syndrome and a history of two unexplained transient ...

OBJECTIVE To investigate whether typical neuropathological and radiological findings can be identified in patients with the clinical diagnosis of the Heidenhain variant of Creutzfeldt-Jakob disease (CJD). DESIGN Case study. The clinical symptoms, neuropathological findings, electroencephalograms, magnetic resonance images, and cerebrospinal fluid samples of 14 Heidenhain cases were evaluated....

The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) - the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain - causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain ...

The neuropathological hallmark of Parkinson’s disease (PD) is the accumulation alpha–synuclein (AS) aggregates. identification AS aggregates in gut biopsy specimens from people with PD may provide an opportunity to identify at a very early stage, prior symptom onset. Changes microbiota and inflammatory conditions (such as periodontitis) be linked onset/evolution. This project aims explore conce...

Background and purpose Clinical diagnostic criteria for neurodegenerative diseases have been framed based on clinical phenomenology. However, systematic knowledge about the first reported symptoms in is lacking. Therefore, aim was to determine prevalence implications of symptom (FS) as assessed by medical history neuropathologically proven diseases. Methods Neuropathological diagnoses from Neur...

alzheimer’s disease (ad) is a uniquely human disorder. although the pathogenesis of ad is not fully understood, growing evidence indicates that the deposition of beta-amyloid (aβ) and the local reactions of various cell types to this protein play major roles in the development of the disease. in the present study transgenic mice expressing mutant amyloid precursor protein (app) has been used. t...

To advance disease-modifying therapies, it is critical to understand the relationship between the neuropathological changes of Alzheimer's Disease (AD) and the clinical measures used in therapeutic trials. We reviewed neuropathologically proven cases of AD from the National Alzheimer's Coordinating Center (NACC) and examined correlations between neuropathological changes and clinical-trial rela...