BACKGROUND Treatment of recurrent anaplastic glioma and glioblastoma remains a particular challenge in neurooncology. The lack of controlled trials results in poor evidence for all therapeutic options. Upon recurrence, many patients are treated with bevacizumab or one of the frequently used nitrosoureas such as lomustine. However, patients who still present in overall good condition after failu...

Routine therapeutic options for tumors of the brain or spinal cord comprise surgery, radiation and/or chemotherapy, all of which are associated with several possible complications. The most important consequences of brain tumor therapy are hemorrhage, acute brain swelling with external herniation of parts of the brain, CSF leaks, and coagulopathies. The anatomical location of surgical manipulat...

Recent research in brain imaging has highlighted the role of different neural networks in the resting state (ie, no task) in which the brain displays spontaneous low-frequency neuronal oscillations. These can be indirectly measured with resting-state functional magnetic resonance imaging, and functional connectivity can be inferred as the spatiotemporal correlations of this signal. This techniq...

Trigeminal schwannoma is a neurogenic tumor of the fifth cranial nerve. Despite advances in surgical practice, stereotactic radiosurgery an alternative treatment management these patients due to problems such as nerve injuries and accessibility The patient was admitted our hospital with complaints headache tingling left face for last few months. discussed neurooncology council intervention not ...

BACKGROUND Malignant gliomas account for a high proportion of brain tumours. With new advances in neurooncology, the recurrence-free survival of patients with malignant gliomas has been substantially prolonged. It, however, remains dependent on the thoroughness of the surgical resection. The maximal tumour resection without additional postoperative deficit is the goal of surgery on patients wit...

3745 NUCLEAR OVERHAUSER ENHANCEMENT (NOE) MEDIATED CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) IMAGING AT 7 TESLA IN GLIOBLASTOMA PATIENTS Daniel Paech, Jan Eric Meissner, Johannes Windschuh, Benedikt Wiestler, Jan Oliver Neumann, Heinz Peter Schlemmer, Wolfgang Wick, Armin Nagel, Marc Ladd, Martin Bendszus, Peter Bachert, Moritz Zaiss, and Alexander Radbruch Department of Neuroradiology, Univ...

Liposomes have long been effective delivery vehicles for transport of toxins to peripheral cancers. The combination of convection-enhanced delivery (CED) with liposomal toxins was originally proposed to circumvent the limited delivery of intravascular liposomes to the central nervous system (CNS) due to the blood-brain-barrier (BBB). CED offers markedly improved distribution of infused therapeu...

Quality of life is an important area of clinical neurooncology that is increasingly relevant as survivorship increases and as patients experience potential morbidities associated with new therapies. This review of quality-of-life studies in the brain tumor population aims to summarize what is currently known about quality of life in patients with both low-grade and high-grade tumors and suggest...

Pseudophenomena, that is, imaging alterations due to therapy rather than tumor evolution, have an important impact on the management of glioma patients and the results of clinical trials. RANO (response assessment in neurooncology) criteria, including conventional MRI (cMRI), addressed the issues of pseudoprogression after radiotherapy and concomitant chemotherapy and pseudoresponse during anti...