With more of the world's population surviving longer, individuals often face age-related neurology disorders and decline of function that can affect lifestyle and well-being. Despite neurophysiological changes affecting the brain function and structure, the aged brain, in some degree, can learn and relearn due to neuroplasticity. Recent advances in rehabilitation techniques have produced better...

Neurological conditions affecting the hip pose a considerable challenge in replacement surgery since poor and imbalanced muscle tone predisposes to dislocation and loosening. Consequently, total hip replacement (THR) is rarely performed in such patients. In a systematic review of the literature concerning THR in neurological conditions, we found only 13 studies which described the outcome. We h...

OBJECTIVE To retrospectively review the clinical case records of patients with idiopathic vocal cord palsies (VCPs) for the presence of preexisting or subsequent development of neurological disease, including multiple sclerosis, motor neuron disease, myasthenia gravis, cerebrovascular disease, and Guillain-Barré syndrome. DESIGN Retrospective case review of all patients with VCP presenting se...

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Chronic neurological illnesses such as Alzheimer’s Disease are the most pressing public health problems in aging societies. Biomedical and mechanistic approaches to these degenerative conditions are limited by incomplete knowledge of the initiating causes and basic mechanisms of pathogenesis. Proposed treatments such as monoclonal antibodies are built on disputed notions of the role of patholog...

Although English government policy has encouraged the implementation of self-management programmes in services for people with long-term conditions, the evidence for their efficacy has been limited. People with long-term neurological conditions use community-based health services including community nursing, and have particular needs in regards to self-management. This article provides an overv...

OBJECTIVES To estimate and compare the costs of informal and formal care provided to adults with long term neurological conditions and to identify characteristics associated with these costs. DESIGN Cross-sectional postal questionnaire survey. PARTICIPANTS Family carers of 282 adults with sudden onset, progressive and stable/intermittent conditions were recruited through UK-wide voluntary o...

CME Objectives Upon completion of this article, you should be able to: 1. Describe indications for neuroimaging for a variety of clinical presentations. 2. Describe a systematic approach to the interpretation of non-contrast head CT. 3. Select the most appropriate imaging modality for a variety of acute neurological complaints. 4. Compare and contrast CT and MR in terms of sensitivity and speci...

Neuronal plasticity is an essential property of the brain that is impaired in different neurological conditions. Phosphodiesterase type 1 (PDE1) inhibitors can enhance levels of the second messengers cAMP/cGMP leading to the expression of neuronal plasticity-related genes, neurotrophic factors, and neuroprotective molecules. These neuronal plasticity enhancement properties make PDE1 inhibitors ...