BACKGROUND AND OBJECTIVES The screening of candidates for heart transplantation continues to present difficulties. High plasma levels of cytokines and neurohormones have been associated with a poor prognosis in heart failure but their usefulness for identifying candidates for heart transplantation is still not established. METHODS In 83 patients (59 11 years old), with systolic left ventricul...

-type natriuretic peptides (BNP and N-terminal [NT]roBNP) have been shown to be extremely helpful in the iagnosis, prognosis, and monitoring of therapy of patients ith heart failure (HF) (1). These neurohormones are preominately secreted from the left and the right cardiac ventricle n response to cardiac stress. The BNPs can be seen as uantitative markers of HF summarizing the extent of systoli...

The effects of potential neurohormones on the intracellular concentrations of adenosine 3':5'-cyclic monophosphate have been examined with three clonal lines of cultured glial tumors. In all cases, norepinephrine and isoproterenol produced striking elevations of the intracellular concentrations of the cyclic nucleotide. The response was mediated by a beta-adrenergic receptor. This effect is hyp...

The aim of this study was to evaluate differences in the effects of Qi therapy without touching or with touching on anxiety, mood, neurohormones, and cellular immune function. Twenty-four healthy male subjects were randomly assigned to either QTN (n = 12) or QTT (n = 12). They received Qi therapy (external Qigong) without touching (QTN) or with touching (QTT). Nonparametric statistical tests re...

We demonstrate here that a specific monoclonal antibody can be utilized as a physiological tool to analyze neuropeptide function. Two cardioacceleratory peptides (CAPs) have been recently isolated from the CNS of the tobacco hawkmoth, Manduca sexta (Tublitz and Truman, 1985a), and it has been suggested that they act as cardioregulatory neurohormones during adult emergence and wing inflation (Tu...

Homeostasis in the intact organism is achieved implicitly by repeated incremental feedback (inhibitory) and feedforward (stimulatory) adjustments enforced via intermittent signal exchange. In separated systems, neurohormone signals act deterministically on target cells via quantifiable effector-response functions. On the other hand, in vivo interglandular signaling dynamics have not been estima...