A case of huge occipital myxomatous plexiform neurofibroma is presented. The lesion slowly enlarged since childhood and was associated with suboccipital bone hypoplasia. At operation the lesion was clearly originating from the occipital nerve and was totally excised. The case represents a rare occurrence of occipital myxomatous plexiform neurofibroma and suboccipital bone hypoplasia in the abse...

Classically, the different subtypes of the peripheral nerve sheets tumors display typical morphological features which differentiate them from the other nervous tumors. Either schwannoma or neurofibroma have characteristic histological and immunohistochemical features. We present a case of peripheral nerve sheets hybrid tumor which have had histological and immunohistochemical features of neuro...

Neurofibromatosis type 1 (NF1) is the most common genetic disorder with a predisposition to malignancy and affects 1 in 3500 persons worldwide. NF1 is caused by a mutation in the NF1 tumor suppressor gene that encodes the protein neurofibromin. Patients with NF1 have cutaneous, diffuse, and plexiform neurofibromas, tumors comprised primarily of Schwann cells, blood vessels, fibroblasts, and mas...

AIMS To compare the expression of immunohistochemical variables between benign and malignant components of malignant peripheral nerve sheath tumour (MPNST) arising within neurofibroma. METHODS Eight cases of MPNST arising within a neurofibroma, associated with neurofibromatosis type 1 (NF1), were studied. The areas of MPNST and neurofibroma were compared immunohistochemically with regard to t...

Neurofibroma of the prostate is an extremely rare benign tumor, particularly when it is not associated with neurofibromatosis-I (NF-1). This study aimed to report the case of a 44-year-old man who presented with dysuria for about 4 years. Magnetic resonance imaging (MRI) showed a mass in the prostate with “target sign” on T2-weighted imaging. The mass was surgically excised, and histopathologic...

BACKGROUND Pelvic masses are a common gynecologic problem, and majority of them are diagnosed as ovarian tumors finally. Sometimes, it is hard to distinguish the origin of these pelvic masses. The following case is a solitary neurofibroma arising from the right-side obturator nerve, which was impressed as a right-side ovarian tumor initially. We reported this case, and also performed a PRISMA-d...

Neurofibromas are benign peripheral nerve sheath tumours, which are usually solitary and sporadic. Solitary neurofibromas of the breast are rare. The most common location of a breast neurofibroma is the nipple-areola complex. We report a rare case of a 56-year-old woman with a solitary neurofibroma of the right breast sulcus.

background and objective: neurofibromas occur as solitary and multiple forms. the solitary ones are extraneural and more common, histologically exhibiting spindle cells with wavy nuclei, scattered among collagen fibers. multiple neurofibromas are seen in neurofibromatosis (types i and ii), including intraneural (plexiform, cutaneous deep circumscribed) and extraneural (cutaneous, deep diffuse) ...

purpose: to assess the histopathological and immunohistochemical features of orbital spindle cell tumors. methods: a descriptive, retrospective study was performed on 63 pathology reports on all types of orbital spindle cell tumors at the pathology department of farabi hospital between 1995 and 2005. immunohistochemistry studies for different markers, such as smooth muscle actin, desmin, s100 p...