Functional hubs are brain regions that play a crucial role in facilitating communication among parallel, distributed brain networks. The developmental emergence and stability of hubs, however, is not well understood. The current study used measures of network topology drawn from graph theory to investigate the development of functional hubs in 99 participants, 10-20 years of age. We found that ...

This paper approaches the problem of designing a two-level network protected against single-edge failures. The problem simultaneously decides on the partition of the set of nodes into terminals and hubs, the connection of the hubs through a backbone network (first network level), and the assignment of terminals to hubs and their connection through access networks (second network level). We cons...

Many online social networking websites allow arbitrary Web users to easily add popular users, such as famous celebrities and musicians, into their circle of friends. Such popular users, or “hubs,” have a large number of connections in the social network. However, most online social networks treat such hubs in much the same way as they do ordinary users in terms of security and privacy. In this ...

Intrinsic disorder and distributed surface charge have been previously identified as some of the characteristics that differentiate hubs (proteins with a large number of interactions) from non-hubs in protein-protein interaction networks. In this study, we investigated the differences in the quantity, diversity, and functional nature of Pfam domains, and their relationship with intrinsic disord...

Small-world properties have been demonstrated for many complex networks. Here, we applied the discrete wavelet transform to functional magnetic resonance imaging (fMRI) time series, acquired from healthy volunteers in the resting state, to estimate frequency-dependent correlation matrices characterizing functional connectivity between 90 cortical and subcortical regions. After thresholding the ...

Studies of nervous system connectivity, in a wide variety of species and at different scales of resolution, have identified several highly conserved motifs of network organization. One such motif is a heterogeneous distribution of connectivity across neural elements, such that some elements act as highly connected and functionally important network hubs. These brain network hubs are also densel...