Experiments were performed on 48 albino rats. All experimental animals were initially trained to a balancing instrumental conditioned reflex (ICR). Unilateral bulbar pyramidotomy performed in 24 rats caused contralateral hemiparesis. On the next day following the operation 12 rats (first group) were injected intramuscularly with bacterial melanin (BM) solution. Recovery periods of ICR and paral...

We used the fluorescence recovery after photobleaching technique to monitor movements of synaptic vesicles in top views of living frog motor nerve terminals that had been prestained with the fluorescent dye FM1-43. In each experiment, a small portion of a single stained vesicle cluster was bleached with a laser and monitored subsequently for signs of recovery as neighboring, unbleached vesicles...

Functional recovery following experimental nerve injury has been notoriously difficult to quantify precisely. The current gold standard in the rat sciatic nerve model involves analysis of footprints of the recovering animal, and computation of the sciatic function index (SFI). We performed transection injuries and measured recovery both by walking track analysis and by a newer, simpler, more qu...

OBJECTIVE The present study aimed to clarify the structural recovery, and to compare the time course of morphological changes in trabeculae and the process of bone mass change in rat tibiae following temporary immobilization of hind limb by sciatic neurectomy or nerve freezing. METHODS In 11-week-old male Fischer 344 rats, 4-5 mm of the sciatic nerve was removed (neurectomy group) or frozen b...

purpose: to evaluate the effect of botulinum toxin-a as an alternate to surgery in acute complete sixth nerve palsy and to shorten the recovery period. methods: thirty patients with acute complete sixth nerve palsy received 1-10 units of botulinum toxin-a (dysport) injection in the medial rectus muscle within one month from the onset of palsy. toxin was injected directly into the muscle belly u...

A 25-years-old woman with mandibular prognathism underwent a mandibular setback by way of mandibular sagittal split ramus osteotomy (MSSRO). After 2 days of operation, she developed difficulty of closing her right eye. The blink reflex test and motor nerve conduction study of the right orbicularis oris muscle were revealed right facial neuropathy of unknown origin and House-Brackmann facial ner...

The natural history of idiopathic abducens nerve paresis and the role of conservative management such as vision training during the recovery process is not well documented in the literature to the best of our knowledge. This case report presents the natural recovery process of idiopathic abducens nerve paresis in a young adult and the role of vision therapy in the recovery process.

IntroductIon: Peripheral nerve injury is a common and debilitating consequence of traumatic injury. Surgical repair of peripheral nerve by repositioning results in a degree of nerve regeneration and functional recovery. However, the clinical outcome, particularly in long length nerve defects, is disappointing and research continues to develop approaches to optimize functional recovery. An appro...

IntroductIon: Peripheral nerve injury is a common and debilitating consequence of traumatic injury. Surgical repair of peripheral nerve by repositioning results in a degree of nerve regeneration and functional recovery. However, the clinical outcome, particularly in long length nerve defects, is disappointing and research continues to develop approaches to optimize functional recovery. An appro...

background:   valproic acid (vpa) is used to be an effective anti-epileptic drug and mood stabilizer. it has recently been demonstrated that vpa could promote neurite outgrowth, activate the extracellular signal regulated kinase pathway, and increases bcl-2 and growth cone-associated protein 43 levels in spinal cord. in the present research we demonstrate the effect of vpa on peripheral nerve r...