Introduction. This study was aimed to assess the ratio of total cholesterol (TC) to high-density density lipoprotein cholesterol (HDLC) and plasma nitrate levels in patients with ischemic nephropathy receiving statins and niacin extended release (NER). Materials and Methods. Kidney disease patients with a history of at least 5 year of diabetes mellitus or 10 year of hypertension were screened b...

Nucleotide excision repair (NER) removes a variety of DNA lesions. Using a yeast cell-free repair system, we have analyzed the repair synthesis step of NER. NER was proficient in yeast mutant cell-free extracts lacking DNA polymerases (Pol) beta, zeta or eta. Base excision repair was also proficient without Polbeta. Repair synthesis of NER was not affected by thermal inactivation of the tempera...

This paper shows the implementation of named entity recognition (NER) which is one of the applications of Natural Language Processing and is regarded as the subtask of information retrieval. NER is the process to detect Named Entities (NEs) in a document and to categorize them into certain Named entity classes such as the name of organization, person, location, sport, river, city, country, quan...

Nucleotide excision repair (NER) removes damage from DNA in a tightly regulated multiprotein process. The xeroderma pigmentosum group B (XPB) helicase subunit of TFIIH functions in NER and transcription. The serine 751 (S751) residue of XPB was found to be phosphorylated in vivo. This phosphorylation inhibits NER and the microinjection of a phosphomimicking XPB-S751E mutant is unable to correct...

This paper describes how a machinelearning named entity recognizer (NER) on upper case text can be improved by using a mixed case NER and some unlabeled text. The mixed case NER can be used to tag some unlabeled mixed case text, which are then used as additional training material for the upper case NER. We show that this approach reduces the performance gap between the mixed case NER and the up...

Name entity recognition (NER) is an important subtask in natural language processing. Various NER systems have been developed in the last decade. They may target for different domains, employ different methodologies, work on different languages, detect different types of entities, and support different inputs and output formats. These conditions make it difficult for a user to select the right ...

Dieser Beitrag befasst sich mit der Validierung von Named Entity Recognition (NER), einem Verfahren, das als Teilschritt Inhaltsanalyse umfangreichen Textdaten eingesetzt werden kann und auf die automatisierte Identifikation Extraktion Eigennamen (Personen, Organisationen, Orte) in Texten spezialisiert ist. Für diesen Zweck oft frei verfügbare NER-Softwarepakete verwendet, spezifischen trainier...

Nucleotide excision repair (NER) removes a plethora of DNA lesions. It is performed by a large multisubunit protein complex that finds and repairs damaged DNA in different chromatin contexts and nuclear domains. The nucleolus is the most transcriptionally active domain, and in yeast, transcription-coupled NER occurs in RNA polymerase I-transcribed genes (rDNA). Here we have analyzed the roles o...

TFIIH is indispensable for nucleotide excision repair (NER) and RNA polymerase II transcription. Its tenth subunit was recently discovered in yeast as Tfb5. Unlike other TFIIH subunits, Tfb5 is not essential for cell survival. We have analyzed the role of Tfb5 in NER. NER was deficient in the tfb5 deletion mutant cell extracts, and was specifically complemented by purified Tfb5 protein. In cont...

Nucleotide excision repair (NER) removes the major UV photolesions from cellular DNA. In humans, compromised NER activity is the cause of several photosensitive diseases, one of which is the skin-cancer predisposition disorder, xeroderma pigmentosum (XP). Two assays commonly used in measurement of NER activity are 'Unscheduled DNA synthesis (UDS)', and 'Recovery of RNA synthesis (RRS)', the lat...