The selective cyclooxygenase-2 (COX-2) and 5-lipoxygenase (LOX) inhibitors might inhibit prostaglandin synthesis and reduce proteinuria. The present study was designed to investigate the anti-proteinuric effects of nordihydroguaiaretic acid (NDGA) as compared with celecoxib in puromycin aminonucleoside (PAN) nephrosis rats. Fifty five male Sprague-Dawley rats were divided into 4 groups; A, norm...

Many attempts have been made to classify renal diseases in general and glomerulonephritis in particular since Richard Bright (1836) reported his classical researches into the clinical and pathological changes in his patients suffering from kidney disease. The word nephrosis was coined by Muller (1905) to define a clinical condition characterized by oedema, albuminuria, and hypoproteinaemia. Vol...

Results from several radical scavenger studies indirectly suggested an involvement of reactive oxygen species in the pathogenesis of puromycin aminonucleoside glomerulopathy. In this study, generation of reactive oxygen species was examined directly in glomeruli isolated from rats in the acute phase of puromycin aminonucleoside nephrosis and related to the changes in the glomerular antioxidant ...

Edema and ascites in nephrotic syndrome mainly result from increased Na+ reabsorption along connecting tubules and cortical collecting ducts (CCD). In puromycin aminonucleoside (PAN)-induced nephrosis, increased Na+ reabsorption is associated with increased activity of the epithelial sodium channel (ENaC) and Na+,K+-ATPase, two targets of aldosterone. Because plasma aldosterone increases in PAN...

This review covers lipids, apolipoproteins, and receptors involved in the dyslipidemia of the nephrotic syndrome in humans and in rat or mouse models of the syndrome. It emphasizes research published during the last decade, though earlier work is cited. The focus is on the biosynthesis and catabolism of the plasma lipoprotein density classes and the role of receptors and enzymes in regulating l...

Serum lipid and lipoprotein alterations in nephrosis were discussed in detail in a previous report (1). It was found that there were qualitative as well as quantitative differences in lipoproteins from one patient to another. Despite the differences in lipoprotein pattern, concentrations of serum cholesterol and phospholipids were related inversely to concentrations of serum albumin in a fairly...