Cisplatin is widely used chemotherapeutic agent for the treatment of several human malignancies. The efficacy is dose dependent, but the significant risk of nephrotoxicity frequently inhibits the use of higher doses to maximize its anti-neoplastic effects. In the present investigation, the Avuri kudineer [Decoction of Indigofera tinctoria] made of indigo leaves AKL, the Avuri kudineer made of i...

Background. The nephroprotective effect of vitamins E and C or losartan against cisplatin (CP)- induced nephrotoxicity when they are accompanied by estrogen was investigated. Methods. The ovariectomized rats received estradiol valerate for two weeks. At the end of the first week, a single dose of CP (7 mg/kg, IP) was also administered, and they received placebo (group 1), vitamin E (group 2), v...

Trifolium alexandrinum is traditionally used in various human ailments, including renal dysfunctions. The present experiment was designed to investigate antioxidant and nephroprotective effect of T. alexandrinum methanolic extract (TAME) against CCl4-induced oxidative stress in albino rats. Results of in vitro study revealed significant (P < 0.05) antioxidant effects. The ameliorative role of T...

Environmental pollution from pesticides is an important issue that attracts wide spread public concern. Among these organophosphate pesticides are routinely used in agriculture. Chloropyrifos toxicity has been largely associated with irreversible inhibition of acetyl-cholinesterase resulting in accumulation of acetylcholine in the cholinergic receptors. Organochlorine insecticides, caused degen...

The nephrotoxicity of aristolochic acid (AA) is well known, but information regarding the attenuation of AA-induced toxicity is limited. The aim of the present study was to study the nephroprotective effects of resveratrol (Resv) and ursolic acid (UA) in a zebrafish model. We used two transgenic lines, Tg(wt1b:EGFP) and Tg(gata1:DsRed), to evaluate the nephroprotective effects of Resv and UA by...