CLINICALCHEMISTRY, Vol. 34, No. 2, 1988 461 3. Huber C, Batchelor JR, Fuchs D, et al. Immune response-associatedproduction of neopterin-release from macrophages primanly under control of interferon-gamma. J Exp Med 1984;160:310-6. 4. Nathan CF. Peroxide and pteridine: a hypothesis onthe regulationof macrophage antimicrobial activity by interferon-gainma. In: Greaser I, Vilcek J, eds.Interferon,...

Polarized human T helper (Th) cells play a key role in the network of the specific immune system compartments. Cell-mediated immune response depends on activation of Th1-type cells, typically producing and releasing interferon-gamma and interleukin-2, whereas activation of Th2-type cells and production of cytokines such as interleukin-4, -5, and -10 are involved in humoral immune response and t...

Determinations of neopterin levels reflect the stage of activation of the cellular immune system which is of importance in the pathogenesis and progression of various diseases, e.g., in viral infections, in autoimmune or inflammatory diseases, rejection episodes following allograft transplantation and in several malignant diseases. Besides the importance of neopterin as a diagnostic marker new ...

BACKGROUND Crystalline silica is a commonly used mineral in various industries and construction activities, and it is so important introducing potential biomarkers to identify early indicators of biological effects in its high-risk occupational exposures. AIM The present study was aimed to assess the blood and urinary neopterin as an early biomarker of exposure in the workers of an insulator ...

OBJECTIVE To evaluate neopterin plasma concentrations in patients with active juvenile idiopathic arthritis (JIA) and correlate them with disease activity. METHODS Sixty patients diagnosed as active JIA, as well as another 60 apparently healthy age- and gender-matched children as controls, were recruited from the Pediatrics Allergy and Immunology Clinic, Ain Shams University. Disease activity...

OBJECTIVE The objective of this study was to evaluate neopterin plasma concentrations in patients with early Rheumatoid Arthritis (RA) and correlate them with disease activity. METHODS This is a 28-month prospective study carried out on 65 individuals. There were 27 patients with early RA and 38 healthy volunteers as control group. Enzyme immunoassay was used to measure concentrations of neop...

HIV-1 invades the central nervous system (CNS) in the context of acute infection, persists thereafter in the absence of treatment, and leads to chronic intrathecal immunoactivation that can be measured by the macrophage activation marker, neopterin, in cerebrospinal fluid (CSF). In this review we describe our experience with CSF neopterin measurements in 382 untreated HIV-infected patients acro...

OBJECTIVE To assess whether neopterin concentrations in women with unstable angina differ from those in women with chronic stable angina. DESIGN Prospective cohort study. SETTING University hospital in south west London. PATIENTS 114 consecutive women with angina were studied: 82 had chronic stable angina (typical exertional chest pain, positive exercise ECG testing, and/or abnormal myoca...

Breast cancer is the commonest malignancy of women in many parts of the world and comprises 18% of all female cancers. There is one million new cases in the world each year. Neopterin which is a pteridine produced by activation of monocytes by IFN-g may be used as a marker of immune system activation. The biological function of neopterin is still largely unknown and certain pathophysiologic rol...

We assessed the value of urinary neopterin concentrations for prognosis of disease progression in HIV-1-infected patients. Sixty-eight anti-HIV-1 seropositive homosexuals with lymphadenopathy syndrome were tested for urinary neopterin and T-cell subset counts in 1982-83, and the incidence rate at which they developed acquired immunodeficiency syndrome (AIDS) between then and May 1988 was evalua...