Tumor suppressor proteins are believed to play a role in regulating cell cycle control during mammalian development. The E6 and E7 oncoproteins from human papillomavirus type 16 are known to affect cell growth control, at least in part, through their inactivation of cellular tumor suppressor gene products, p53 and Rb, respectively. Therefore, these viral proteins can serve as trans-dominant rep...

Caffey’s disease was characterized by a triad of symptoms, irritability, soft tissue swelling, and underlying cortical bone thickening. It mostly occurs before the first 5 months life in infancy. The knowledge this pathology essential as it masquerades wide range diseases including acute osteomyelitis, tumors, trauma, battered baby syndrome (child abuse), hypervitaminosis a, scurvy, infantile m...

background:   although the majority of soft tissue masses are benign, it is important to consider malignancy in differential diagnoses. because most soft tissue sarcomas present as a painless mass, clinicians must watch for signs suggestive of malignancy, including large size, rapid growth, and site deep into the deep fascia.the purpose of this study was to determine the relative prevalence acc...

background pancreatic neuroendocrine tumors (pnets) are rare tumors with variable malignant potential, prognosis, and survival. we aimed to assess the characteristics of patients with non- functional pnet  in our hospital . methods from nov 2010 to nov 2013 , all patients who came to endosonography unit of shariati  hospital , tehran , iran , and   had pancreatic lesions were assessed . tumor s...

abdominal masses in neonatal period is one of the main causes of patients bed ridden in infantal surgery wards. the rapid encounterance with these patients has caused a decrease in mortality and morbidity. this study is a kind of historical research which has been conducted on data base management systems of two above mentioned hospitals between years 1361-1378. the final outcome was only 25 ca...

The role of organochlorine (OC) exposure in the etiology of breast cancer remains controversial. Thus, our objective was to determine whether the most abundant and toxic OCs found in human milk could, when ingested during the neonatal period, modulate the development of mammary tumors in the rat. We prepared a mixture composed of p,p'-dichlorodiphenyltrichloroethane (DDT), its major metabolite,...

Background: Regarding the significance of abdominal masses in children, we aimed to identify the pathology of masses according to the age and sex groups. Materials and Methods: We retrospectively reviewed pathological reports of 461 patients with abdominal mass that underwent resection or biopsy during the study period (25 years). Results: One hundred and eighty six cases (40%) were non-neo...

sepsis is the most common cause of neonatal mortality. as per national neonatal-perinatal database (nnpd), 2002-2003, the incidence of neonatal sepsis in india was 30 per 1000 live births. signs and symptoms of sepsis are nonspecific; therefore empirical antimicrobial therapy is promptly initiated after obtaining appropriate cultures. the early manifestations of neonatal sepsis are vague and il...

background: neonatal infections are one of the major causes of death in iran. since identifying the risk factors, types, site, bacterial causes, and case fatality rate of an infection can be effective in selecting preventive and therapeutic methods, and appropriate supportive measures, this study aimed to investigate the aforementioned factors in the neonatal intensive care unit (nicu) of ghaem...