Seizures induce excitatory shifts in the reversal potential for GABA(A)-receptor-mediated responses, which may contribute to the intractability of electro-encephalographic seizures and preclude the efficacy of widely used GABAergic anticonvulsants such as phenobarbital. We now report that, in intact hippocampi prepared from neonatal rats and transgenic mice expressing Clomeleon, recurrent seizu...

Ischemia in the immature brain is an important cause of neonatal seizures. Temporal evolution of acquired neonatal seizures and their response to anticonvulsants are of great interest, given the unreliability of the clinical correlates and poor efficacy of first-line anti-seizure drugs. The expression and function of the electroneutral chloride co-transporters KCC2 and NKCC1 influence the anti-...

Abstract Background: Convulsion in neonatal period is a considerable clinical issue because of its potential brain damage.One of the benign neonatal seizures known as the  fifth day fits ,is due to zinc deficiency. Zinc is a rare element which has spread throughout the body fluids and tissues especially central nervous system. Reduction of neurons’ stimulation has been ascribed as the main eff...

AIM To determine if cerebral blood flow velocity increases during all types of neonatal seizure, and whether the effect is due solely to an increase in blood pressure, transmitted to the cerebral circulation when autoregulation is impaired. METHODS Seizures were diagnosed in 11 high risk neonates using cotside 16 channel video-EEG polygraphy. EEG, cerebral blood flow velocity (CBFV) using tra...

BACKGROUND There is controversy over whether seizures, the most common manifestation of neonatal brain injury, may themselves damage the developing brain. OBJECTIVE To determine if neonatal seizures are independently associated with brain injury in newborns with perinatal asphyxia. METHODS Ninety term neonates were studied with MRI and single-voxel (1)H-MRS on median day of life 6 (range 1 ...

Clinical diagnosis of neonatal seizure is difficult and repeated seizures may be unrecognised. To assist in early diagnosis we recorded continuously the electroencephalogram (EEG) of very sick newborns while intensive care continued. In 25 babies at high risk of seizure a continuous record of two channels of EEG, ECG, and respiration was made for periods varying from 11 hours to 16 days. The me...

Incidence of seizure in first year of life is very high. There is a sharp difference between neonatal and post neonatal seizures in infants with respect to etiology, seismology, E.E.G and imaging outcomes and final prognosis. This was an observational prospective study conducted at G.B Panth Childrens’ hospital Srinagar. A detailed history was also sought regarding other variables relevant to t...

how to cite this article: talebian a, jahangiri m, rabiee m, masoudi alavi n, akbari h, sadat z. the etiology and clinical evaluations of neonatal seizures in kashan, iran. iran j child neurol. spring 2015;9(2):29-41.   abstract objective detection of seizure, its etiology, and clinical types is important for guiding therapy. this study was designed to evaluate the etiology and clinical evaluat...