The purposes of this study were to examine symptom patterns and diminished general well-being as negative outcomes and vigor and change as positive outcomes of trait and state anger via two structural equation models. In a school auditorium, a convenience sample of 141 boys and girls, ages 12-14 years, responded to the Trait Anger Scale and the State Anger Scale and to instruments measuring gen...

Harris, German and Mills (Children's use of counterfactual thinking in causal reasoning. Cognition, 61 (1996), 223± 259), following Mackie, argue that children make explicit use of counterfactual thinking in arriving at causal judgments. They showed that children as young as 3, in explaining simple mishap events, made reference to courses of action that a protagonist had rejected, when that cou...

UNLABELLED Drug interactions may represent an iatrogenic risk that should be controlled in community pharmacies at the dispensing level. AIM We analyzed the association between potential drug-drug interactions (DDIs) and negative clinical outcomes. METHODS WE USED DISPENSING DATA FROM TWO COMMUNITY PHARMACIES: instances where drug dispensing was associated with a potential DDI and a compari...

OBJECTIVES Antimitochondrial antibodies (AMA) are a sensitive and specific marker for primary biliary cirrhosis (PBC). AMAs are present in 95% of patients with PBC. However, 5% do not have AMAs and data on these patients is scarce. We aim to evaluate the long-term outcomes of patients with AMA negative PBC. METHODS A retrospective chart review of 71 AMA negative PBC patients. Disease presenta...

Alzheimer disease (AD) drug development has a high failure rate. Drug development decision making can be improved based on lessons learned from past trials. Improved interpretation of animal models, better pharmacologic characterization in phase I and phase II trials, appropriate sample size, diagnosis of AD with biomarker support, optimization of global recruitment, and avoiding inappropriate ...

Objective The difference between positive and negative outcomes is important in trial-and-error decision-making processes and affects corticospinal excitability. This study investigated corticospinal excitability during the performance of trial-and-error decision-making tasks with varying competing behavioral outcomes. Methods Each trial began with one of five colored circles presented as a c...

Peritoneal dialysis (PD) peritonitis and subsequent relapses are undesirable complications for patients requiring home peritoneal dialysis. Coagulase-negative staphylococci (CoNS) remain a common cause of peritonitis. Strains of CoNS are emerging that are resistant to cephalosporins. It has been suggested that, if sensitivity testing shows resistance to cephalosporin but the patient is improvin...