DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.

Background and Objective: Diabetes mellitus is one of the main problems in health systems in the world. Diabetic Foot infections (DFI) is one of the main complications and the most cause  of non-traumatic lower limb amputation .This study aimed to determine the prevalence of bacteria involved in DFI and their antibiotic resistance in patients with DFI diagnosis. Patients and Metho...

Novel analogues of N-piperazinyl fluoroquinolones were prepared and evaluated against a panel of Gram-positive and Gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. Although most of the novel synthesized compounds had lower antibacterial effects, some derivatives show...

The aim of the present study was to evaluate antimicrobial activity of Ganoderma applanatum, Tricholoma giganteum and Bolbitius vitellinus. The methanolic extract of basidiocarps and mycelial mat of all the above mentioned mushrooms was analyzed. The methanolic extracts were tested against three Gram positive, six Gram negative bacteria and two fungal cultures. Out of three mushrooms Ganoderma ...

conclusions the ppi-g2 dendrimer with end amine groups exhibited a positive impact on the removal of dominant bacterial isolated strains. therefore, it is possible to use these nanodendrimers as a safe and effective material for water disinfection in the future. results the most important isolated bacteria were escherichia coli 37 (48.7%), klebsiella oxytoca 12 (15.8%), proteus mirabilis 3 (4%)...

There is a significant interest in developing environmentally responsive or stimuli-responsive smart materials. The purpose of this study was to investigate multi-function cotton fabrics with surface modification on the nanoscale. Three technologies including electrospinning technology, interpenetrating polymer network and cross-linking technology were applied prepare sericin/poly(N-isopropylac...

Novel analogues of N-piperazinyl fluoroquinolones were prepared and evaluated against a panel of Gram-positive and Gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. Although most of the novel synthesized compounds had lower antibacterial effects, some derivatives show...

in many parts of the world there is a rich tradition in the use of herbal medicine for the treatment of many infectious diseases. because of the side effects and the resistance that pathogenic microorganisms build against the antibiotics, much recent attention has been paid to extract the biologically active compounds from plant species used in herbal medicine. in this study different parts of ...

wide range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives. anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the benzoxazinone intermediate; subsequent addition of an amine provided the fused quinazolinones. deoxyvasicinone which wa...