It has been asserted that recent mtDNA phylogenies support the plausibility of sympatric speciation, long considered a controversial mechanism of the origin of species. If such inferences are reliable, mtDNA phylogenies should be congruent with phylogenies based on other data. In previous work, a mtDNA phylogeny suggested that diversification of the Hawaiian cricket genus Laupala was initiated ...

Kajian ini dijalankan untuk mengesan asid deoksiribonukleik (DNA) spesies haiwan dalam campuran minyak sapi menggunakan teknik tindak balas rantaian polimerase (PCR) multipleks. Kebolehdapatan DNA daripada produk berminyak membolehkan analisis PCR dan sekaligus boleh menentukan kehadiran tersebut dengan primer yang khusus-spesies. Gen sasaran adalah mitokondria (mtDNA) Sitokrom oksidase II (COI...

Age-related molecular and cellular alterations in the central nervous system are known to show selectivity for certain cell types and brain regions. Among them age-related accumulation of nuclear (n) DNA damage can lead to irreversible loss of genetic information content. In the present study on the aging mouse brain, we observed a substantial increase in the amount of nDNA single-strand breaks...

Oxidative stress is believed to contribute to the pathogenesis of many diseases, including age-related macular degeneration (AMD). Although the vision loss of AMD results from photoreceptor damage in the central retina, the initial pathogenesis involves degeneration of RPE cells. Evidence from a variety of studies suggests that RPE cells are susceptible to oxidative damage. Mitochondrial DNA (m...

Mitochondrial diseases are the most common inherited inborn error of metabolism resulting in deficient ATP generation, due to failure homeostasis and proper bioenergetics. The frequent mitochondrial disease manifestation children is Leigh syndrome (LS), encompassing clinical, neuroradiological, biochemical, molecular features. It typically affects infants but occurs anytime life. Considering re...

This study builds upon the current understanding of green turtle population genetic structure in Pacific that has largely been based on mitochondrial DNA (mtDNA), by examining nuclear (nDNA) diversity, regional connectivity, and male-mediated gene flow. A total 1,111 nesting samples were analyzed with 10 microsatellite markers from 20 rookeries. Population differentiation (F ST ) was significan...

Cisplatin is one of the most effective and widely used anticancer agents for the treatment of several types of tumors. The cytotoxic effect of cisplatin is thought to be mediated primarily by the generation of nuclear DNA adducts, which, if not repaired, cause cell death as a consequence of DNA replication and transcription blockage. However, the ability of cisplatin to induce nuclear DNA (nDNA...