The exponential growth of complex, heterogeneous, dynamic, and unbounded data, generated by a variety of fields including health, genomics, physics, and climatology pose significant challenges in data processing and desired speed-performance. Existing processorbased (software-only) algorithms are incapable of analyzing and processing this enormous amount of data efficiently and effectively. Con...

TOPIC: Lung Cancer TYPE: Medical Student/Resident Case Reports INTRODUCTION: Bilateral pneumothoraces are a rare occurrence, comprising 1.4% to 7.6% of cases [1]. Secondary causes pneumothorax include bullous emphysema, cystic parenchymal lung disease and tuberculous [2]. Malignancy is cause pneumothorax, yet sarcomas have been associated with in 2% patients [3]. Pazopanib, tyrosine kinase inhi...

Central MessageContrary to long-held belief, this new study suggests that delaying surgical revascularization after acute myocardial infarction may not be desirable in all cases. However, further analyses will required confirm those conclusions.See Article page 2056. Contrary conclusions. See Despite numerous studies having focused on the outcomes of coronary artery bypass grafting (CABG) setti...

Central MessageImproved detection of delirium after cardiac surgery is essential. The 4AT may be an effective screening tool, but further research demonstrating its clinical applicability warranted.See Article page 1151. Improved warranted. See Delirium a common and often under-recognized problem, associated with increased risk probability death hospital readmission, decreased cognitive functio...

Central MessageThe timing of coronary surgery after an acute syndrome appeares to be very important for the surgeons. But does it really matter?See Article page 2056. The matter? See How is artery bypass grafting (CABG) myocardial infarction (MI)? For many years we have been discussing this topic,1Lee D.C. Oz M.C. Weinberg A.D. Windsor T. Appropriate surgical intervention transmural infarction....

Michael A. Thompson, MD, PhD; Jeffrey P. Henderson, Pankil K. Shah, MSPH; Samuel M. Rubinstein, MD; J. Joyner, Toni Choueiri, Daniel B. Flora, PharmD; Elizabeth Griffiths, Anthony Gulati, Clara Hwang, Vadim S. Koshkin, Esperanza Papadopoulos, V. Robilotti, MPH; Christopher T. Su, Wulff-Burchfield, Zhuoer Xie, MS; Peter Paul Yu, Sanjay Mishra, MS, Jonathon W. Senefeld, Dimpy Jeremy L. Warner, CO...

in 1902, well known archibald garrod applied mendels gene concept to human characters. he opened a new window in understanding the etiology of metabolic disorders. he proposed biochemical changes as the etiology of metabolic disorders in his series of papers inborn errors of metabolism (1906). after establishing prenatal diagnosis facilities for the detection of chromosomal abnormalities in our...

Modern research has provided new insights into the biological mechanisms of noise-induced hearing loss, and with these new insights comes hope for possible prevention or treatment. Underlying the classic set of cochlear pathologies that occur as a result of noise exposure are increased levels of reactive oxygen species (ROS) that play a significant role in noise-induced hair cell death. Both ne...